144701-23-5
Methionine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-
CAS: 144701-23-5
Molecular Formula: C20H21NO4S
144701-23-5 - Names and Identifiers
144701-23-5 - Physico-chemical Properties
| Molecular Formula | C20H21NO4S |
| Molar Mass | 371.45 |
144701-23-5 - Introduction
Methionine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-is a commonly used protected amino acid. The following is a description of its nature, use, preparation and safety information:
Nature:
1. Appearance: white or white crystal powder.
2. Solubility: soluble in organic solvents such as dimethylformamide (DMF) and chlorinated methane.
3. Stability: It has good stability under regular reaction conditions.
Use:
Methionine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-Commonly used in peptide Synthesis in Solid-Phase Synthesis as an amino acid protecting group. Its Main uses include:
1. In peptide synthesis, it is used to temporarily protect the α-amino group of methionine to prevent side reactions during the reaction.
2. Construct a polypeptide library to screen polypeptides with biological activity.
Method:
The preparation of Methionine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-usually includes the following steps:
1. Fmoc-phenylalanine and methionine are linked by a condensation reaction.
2. Use alkaline conditions (such as sodium carbonate solution) to decompose the resulting mixture, and purify the product by extraction and crystallization methods.
Safety Information:
1. Methionine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-is a chemical that should be handled in a laboratory environment.
2. Avoid skin contact and inhalation of dust/mist to prevent swallowing.
3. When in use should wear appropriate protective equipment, including gloves, glasses and protective masks.
4. Seek medical advice immediately if you feel unwell or unplanned.
Please note that the use and handling of chemical reagents should follow the laboratory's Safety practices, and refer to the relevant chemical Safety Data Sheet (SDS) for detailed understanding and operating instructions.
Nature:
1. Appearance: white or white crystal powder.
2. Solubility: soluble in organic solvents such as dimethylformamide (DMF) and chlorinated methane.
3. Stability: It has good stability under regular reaction conditions.
Use:
Methionine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-Commonly used in peptide Synthesis in Solid-Phase Synthesis as an amino acid protecting group. Its Main uses include:
1. In peptide synthesis, it is used to temporarily protect the α-amino group of methionine to prevent side reactions during the reaction.
2. Construct a polypeptide library to screen polypeptides with biological activity.
Method:
The preparation of Methionine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-usually includes the following steps:
1. Fmoc-phenylalanine and methionine are linked by a condensation reaction.
2. Use alkaline conditions (such as sodium carbonate solution) to decompose the resulting mixture, and purify the product by extraction and crystallization methods.
Safety Information:
1. Methionine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-is a chemical that should be handled in a laboratory environment.
2. Avoid skin contact and inhalation of dust/mist to prevent swallowing.
3. When in use should wear appropriate protective equipment, including gloves, glasses and protective masks.
4. Seek medical advice immediately if you feel unwell or unplanned.
Please note that the use and handling of chemical reagents should follow the laboratory's Safety practices, and refer to the relevant chemical Safety Data Sheet (SDS) for detailed understanding and operating instructions.
Last Update：2024-04-09 15:17:52
