1448347-49-6
Ivosidenib
CAS: 1448347-49-6
Molecular Formula: C28H22ClF3N6O3
1448347-49-6 - Names and Identifiers
| Name | Ivosidenib |
| Synonyms | AG120 RG120 AG 120 CS-1721 EOS-60845 Ivosidenib lvosidenib Ivosidenib(AG-120) |
| CAS | 1448347-49-6 |
1448347-49-6 - Physico-chemical Properties
| Molecular Formula | C28H22ClF3N6O3 |
| Molar Mass | 582.96 |
| Density | 1.51±0.1 g/cm3(Predicted) |
| Melting Point | 151-173°C |
| Boling Point | 854.3±65.0 °C(Predicted) |
| Solubility | DMSO: ≥ 39 mg/mL |
| Appearance | Solid |
| Color | White to Off-White |
| pKa | 11.58±0.40(Predicted) |
| Storage Condition | -20°C Freezer, Under inert atmosphere |
| In vitro study | Treatment of TF-1 cells and primary human AML patient samples carrying mutated IDH1 with AG-120 reduced intracellular 2-HG levels, inhibits growth factor-independent cell proliferation and restores erythropoietin-induced cell differentiation in TF-1 IDH1-R132H cells. Similarly, inhibition of mutant IDH1 with AG-120 in primary human blasts was effective in reducing 2-HG levels and inducing myeloid differentiation. |
1448347-49-6 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 1.715 ml | 8.577 ml | 17.154 ml |
| 5 mM | 0.343 ml | 1.715 ml | 3.431 ml |
| 10 mM | 0.172 ml | 0.858 ml | 1.715 ml |
| 5 mM | 0.034 ml | 0.172 ml | 0.343 ml |
Last Update：2024-01-02 23:10:35
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Product Name: Ivosidenib Visit Supplier Webpage Request for quotationCAS: 1448347-49-6
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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