1457-42-7
PYRIDAZINE-N-OXIDE
CAS: 1457-42-7
Molecular Formula: C4H4N2O
1457-42-7 - Names and Identifiers
| Name | PYRIDAZINE-N-OXIDE |
| Synonyms | Pyridazine 1-oxide PYRIDAZINE-N-OXIDE Pyridazine 1-oxide 1-oxidopyridazin-1-ium 4-chlorine-5-Mi oxide pyridazine -3(2H)-ketone |
| CAS | 1457-42-7 |
| EINECS | 200-001-2 |
| InChI | InChI=1/C4H4N2O/c7-6-4-2-1-3-5-6/h1-4H |
1457-42-7 - Physico-chemical Properties
| Molecular Formula | C4H4N2O |
| Molar Mass | 96.09 |
| Density | 1.19g/cm3 |
| Melting Point | 298-305 °C |
| Boling Point | 210.7°C at 760 mmHg |
| Flash Point | 81.2°C |
| Vapor Presure | 0.275mmHg at 25°C |
| Refractive Index | 1.564 |
1457-42-7 - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R22 - Harmful if swallowed R37/38 - Irritating to respiratory system and skin. R41 - Risk of serious damage to eyes |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S39 - Wear eye / face protection. |
| UN IDs | UN 3335 |
| WGK Germany | 3 |
1457-42-7 - Reference Information
| Application | pyridazine N-oxide can be used in organic synthesis reactions, as pharmaceutical intermediates and organic synthesis intermediates, used in laboratory research and development process and chemical and pharmaceutical synthesis process. |
| preparation | pyridazine N-oxide was prepared as follows: the appropriate Diazine (1 equivalent) and mCPBA(1 equivalent) dissolved in DCM(0.2M). The reaction was stirred for 16 hours. PPh3(0.5 eq) was then added to reduce any unreacted peracid and the mixture was stirred for an additional 4 hours. The volatiles were evaporated under reduced pressure and the residue was purified by silica gel column chromatography to give pyridazine N-oxide. |
| Use | coupling partner in Palladium-Catalyzed Direct arylation reactions. |
Last Update：2024-04-10 22:29:15
