145821-59-6
Tiagabine Hcl
CAS: 145821-59-6
Molecular Formula: C20H26ClNO2S2
145821-59-6 - Names and Identifiers
| Name | Tiagabine Hcl |
| Synonyms | GABITRIL Tiagabine Hcl TIAGABINE HYDROCHLORIDE Tiagabine Hydrochloride Tiagabine-d6 hydrochloride THYMOL IODIDE - PURIFIED GRADE Tiagabine Hydrochloride (300 mg) (3R)-1-[4,4-bis(3-methyl-2-thienyl)but-3-enyl]nipecotic acid hydrochloride (3R)-1-[4,4-Bis(3-Methyl-2-thienyl)-3-butenyl]-3-piperidinecarboxylic Acid Hydrochloride 3R)-1-[4,4-Bis(3-methylthiophen-2-yl)but-3-enyl]piperidine-3-carboxylic acid hydrochloride (3R)-1-[4,4-Bis(3-methylthiophen-2-yl)but-3-enyl]piperidine-3-carboxylic acid hydrochloride |
| CAS | 145821-59-6 |
| EINECS | 200-659-6 |
| InChI | InChI=1/C20H25NO2S2.ClH/c1-14-7-11-24-18(14)17(19-15(2)8-12-25-19)6-4-10-21-9-3-5-16(13-21)20(22)23;/h6-8,11-12,16H,3-5,9-10,13H2,1-2H3,(H,22,23);1H/t16-;/m1./s1 |
| InChIKey | YUKARLAABCGMCN-PKLMIRHRSA-N |
145821-59-6 - Physico-chemical Properties
| Molecular Formula | C20H26ClNO2S2 |
| Molar Mass | 412.01 |
| Melting Point | >192oC dec. |
| Boling Point | 568°C at 760 mmHg |
| Specific Rotation(α) | D20 -11° |
| Flash Point | 9℃ |
| Solubility | H2O: soluble10mg/mL, clear |
| Vapor Presure | 9.71E-14mmHg at 25°C |
| Appearance | White to off-white solid |
| Color | white to beige |
| Merck | 14,9417 |
| pKa | pKa1 3.3; pKa2 9.4(at 25℃) |
| Storage Condition | 2-8°C |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO, ethanol, or distilled water may be stored at -20° for up to 3 months. |
| MDL | MFCD07369025 |
| In vitro study | Tiagabine is a potent inhibitor of GABA uptake in neuronal cells and glial cells. It is involved in the regulation of GABA levels, especially in the hippocampus and thalamus. Tiagabine not only affects the decay dynamics of IPSCs, but also reduces the frequency of spontaneous and micro IPSCs. |
| In vivo study | tiagabine was effectively neuroprotective when treated with tiagabine 30 minutes before Cerebral Ischemia in gerbils (but not 3 hours after cerebral ischemia). |
145821-59-6 - Risk and Safety
| Risk Codes | R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R39/23/24/25 - R23/24/25 - Toxic by inhalation, in contact with skin and if swallowed. R11 - Highly Flammable |
| Safety Description | S36/37 - Wear suitable protective clothing and gloves. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S16 - Keep away from sources of ignition. S7 - Keep container tightly closed. |
| UN IDs | UN1230 - class 3 - PG 2 - Methanol, solution |
| WGK Germany | 3 |
| RTECS | TM6128245 |
Supplier List
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Multiple SpecificationsSpot supply
Product Name: Tiagabine Hydrochloride Visit Supplier Webpage Request for quotationCAS: 145821-59-6
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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