146328-85-0
5-BROMO-2-FLUOROBENZOIC ACID
CAS: 146328-85-0
Molecular Formula: C7H4BrFO2
146328-85-0 - Names and Identifiers
| Name | 5-BROMO-2-FLUOROBENZOIC ACID |
| Synonyms | RARECHEM AL BO 0757 5-Bromo-2-fluorobenzoic 5-bromo-2-fluorobenzoate 5-Bromo-2-fluorobenzoicacid 2-FLUORO-5-BROMOBENZOIC ACID 2-Fluoro-5-Bromobenzoic Acid 5-BROMO-2-FLUOROBENZOIC ACID 5-Bromo-2-Fluoro-Benzoic Acid 5-Bromo-2-Fluorobenzoic Acid 2-Fluoro-5-Bromobenzoic Acid |
| CAS | 146328-85-0 |
| EINECS | 604-519-9 |
| InChI | InChI=1/C7H4BrFO2/c8-4-1-2-6(9)5(3-4)7(10)11/h1-3H,(H,10,11)/p-1 |
146328-85-0 - Physico-chemical Properties
| Molecular Formula | C7H4BrFO2 |
| Molar Mass | 219.01 |
| Density | 1.789±0.06 g/cm3(Predicted) |
| Melting Point | 141-145 °C (lit.) |
| Boling Point | 296.5±25.0 °C(Predicted) |
| Flash Point | 133.1°C |
| Water Solubility | Slightly soluble in water. |
| Vapor Presure | 0.000644mmHg at 25°C |
| Appearance | White solid |
| Color | White to Light yellow to Light orange |
| pKa | 2.88±0.10(Predicted) |
| Storage Condition | Sealed in dry,Room Temperature |
| MDL | MFCD00143423 |
146328-85-0 - Risk and Safety
| Risk Codes | 22 - Harmful if swallowed |
| Safety Description | 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| UN IDs | UN 2811 6.1/PG 3 |
| WGK Germany | 3 |
| HS Code | 29163990 |
| Hazard Class | IRRITANT |
| Packing Group | Ⅲ |
146328-85-0 - Reference Information
| uses | 5-bromo-2-fluorobenzoic acid, as an important derivative of benzoic acid, is an important pharmaceutical intermediate and plays an important role in the preparation of anthelmintic drugs and drug synthesis. |
| the synthesis method of preparing | 5-bromo -2-fluorobenzoic acid is as follows: in a 5L four-mouth bottle, 4L of potassium bromide (the mass percentage concentration based on bromine ions is 7.5%) solution is added, 2L of effluent is distilled, 10g of activated carbon is added, decolorization and filtration are carried out, then add flocculant and other precipitates and filters to obtain a potassium bromide solution with a concentration of 15% (mass percentage concentration based on bromine ions); In a four-mouth bottle of 500mI. Add potassium bromide solution (273.5g,0.52mol) with a concentration of 15% (based on the mass percentage concentration of bromine ion juice), slowly add 98% sulfuric acid (48.5g,0.485mol), stir for 30min, add 2-fluorobenzoic acid, raise the temperature to 35 ℃, slowly add 54g(0.152mol) of prepared sodium chlorate solution with a concentration of 30%, and keep the temperature for 30min, raise the temperature to 75 ℃ for 2h, cool to room temperature, filter, wash the cake with water to a pH value of 5~8, and dry to obtain the target compound. |
Last Update：2024-04-09 20:52:54
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