147118-38-5

147118-38-5 - Names and Identifiers

Name	(3R,6E)-3-[[(1,1-Dimethylethyl)dimethylsilyl]oxy]-7-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]-5-oxo-6-heptenoic acid methyl ester
Synonyms	Statin intermediate J8 rui shu Rosuvastatin calcium intermediate J8 (R,E)-Methyl 3-((tert-butyldimethylsilyl)oxy)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethyl (3R,6E)-3-[[(1,1-DiMethylethyl)diMethylsilyl]oxy]-7-[4-(4-fluorophenyl)-6-(1-Methylethyl)-2-[Methyl( (R,E)-Methyl 3-((tert-butyldiMethylsilyl)oxy)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-MethylMethylsulfonaMido)pyriMidin-5-yl)-5-oxohept-6-enoate 6-Heptenoic acid,3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-7-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]-5-o Methyl 7-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonylamino)pyrimidine-5-yl]-(3R)-3-(tert-butyldimethylsilyloxy)-5-oxo-(6E)-heptanoate methyl (3R,6E)-3-{[tert-butyl(dimethyl)silyl]oxy}-7-{4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl}-5-oxohept-6-enoate 7-[4-Fluorophenyl]-6-isopropyl)-2-(N-methyl-N-methylsulfonyl amino)pyrimidine-5-yl]-(3R)-3-(tert-butyldimethylsilyloxy)-5-oxo-6E-heptanoic acid methyl ester (3R,6E)-3-[[(1,1-Dimethylethyl)dimethylsilyl]oxy]-7-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]-5-oxo-6-heptenoic acid methyl ester 6-Heptenoic acid, 3-[[(1,1-diMethylethyl)diMethylsilyl] oxy]-7-[4-(4-fluorophenyl)-6-(1-Methylethyl)-2-[Methyl (Methylsulfonyl)aMino]-5-pyriMidinyl]-5-oxo-, Methyl ester, (3R,6E)-
CAS	147118-38-5
EINECS	604-566-5
InChI	InChI=1/C29H42FN3O6SSi/c1-19(2)26-24(16-15-22(34)17-23(18-25(35)38-7)39-41(9,10)29(3,4)5)27(20-11-13-21(30)14-12-20)32-28(31-26)33(6)40(8,36)37/h11-16,19,23H,17-18H2,1-10H3/b16-15+/t23-/m1/s1

147118-38-5 - Physico-chemical Properties

Molecular Formula	C29H42FN3O6SSi
Molar Mass	607.81
Density	1.168
Boling Point	679.1±65.0 °C(Predicted)
Flash Point	364.5°C
Vapor Presure	2.67E-18mmHg at 25°C
pKa	-0.94±0.10(Predicted)
Storage Condition	2-8°C
Refractive Index	1.528

147118-38-5 - Introduction

(3R,6E)-3-[[(1,1-dimethyllethyl) dimethylsilyl]oxy]-7-[4-(4-fluorophenyl)-6-(1-methyllethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]-5-oxo-6-heptenoic acid methyl ester is a compound commonly abbreviated as MPTF.

Properties of the compound:
-Appearance: colorless or light yellow liquid
-Molecular formula: C23H28FN3O6S
-Molecular weight: 491.55g/mol
-Melting point: No data
-Boiling Point: No data
-Solubility: Soluble in organic solvents such as ethers, ketones and alcohols

Use:
MPTF is often used as a probe for nucleophilic tertiary amines applied to dopamine D2 receptors in chemical research. In addition, it can be used to synthesize organic compounds such as pharmaceuticals and pesticides.

Method:
There are many preparation methods and steps for MPTF, depending on the specific synthesis route and reaction conditions. A common preparation method is to react 4-fluorophenylthiazolecarboxamide with 2-methyl-2-thiopyrimidine in the presence of isopropyl carbamate in an appropriate solvent, and further reacted with TButyl compound to obtain the target product.

Safety Information:
MPTF in the laboratory operation and storage process need to pay attention to the following safety information:
-Irritating to skin, contact with skin should be avoided.
-Avoid inhaling aerosols, fumes, dust and vapors of chemical compounds.
-Wear appropriate protective equipment such as gloves, glasses, and face shields when used.
-Store the compound properly after use in a dry, well-ventilated place.
-Use should comply with relevant regulations and safety procedures.

Last Update：2024-04-09 19:05:46