147128-77-6

147128-77-6 - Names and Identifiers

Name	(4S,6S)-4H-Thieno[2,3-b]-thiopyran-4-ol-5,6-dihydro-6-methyl-7,7-dioxide
Synonyms	Dorzolamide intermediate Dorzolamide hydrochloride seventh step (4R,6S)-5,6-Dihydro-4-hydroxy-6-Methyl thieno2,3-b (4R,6S)-6-Methyl-7,7-dioxo-5,6-dihydro-4H-thieno[2,3-b]thiopyran-4-ol (4R,6S)-5,6-dihydro-6-methyl-4H-thieno[2,3-b]thiopyran-4-ol,7,7-dioxide (4R,6S)-6-methyl-5,6-dihydro-4H-thieno[2,3-b]thiopyran-4-ol 7,7-dioxide (4R,6S)-5,6-Dihydro-6-methyl-4H-thieno[2,3-b]thiopyran-4-ol 7,7-dioxide (4R,6S)-5,6-Dihydro-4-hydroxy-6-methylthieno[2,3-b]thiopyran-7,7-dioxide (4S,6S)-4H-Thieno[2,3-b]-thiopyran-4-ol-5,6-dihydro-6-methyl-7,7-dioxide 4h-thieno[2,3-b]thiopyran-4-ol, 5,6-dihydro-6-methyl-, 7,7-dioxide,(4S,6S) 4H-THIENO[2,3-B]THIOPYRAN-4-OL, 5,6-DIHYDRO-6-METHYL-, 7,7-DIOXIDE, (4S,6S) 5,6-Dihydro-(R,S)-4-acetoxy-(S)-6-methy1 -4H-thieno[2,3-b]thiopyran 7,7-dioxide
CAS	147128-77-6
EINECS	604-572-8
InChI	InChI=1/C8H10O3S2/c1-5-4-7(9)6-2-3-12-8(6)13(5,10)11/h2-3,5,7,9H,4H2,1H3/t5-,7+/m0/s1

147128-77-6 - Physico-chemical Properties

Molecular Formula	C8H10O3S2
Molar Mass	218.29
Density	1.462
Melting Point	154-155 °C
Boling Point	433.3±45.0 °C(Predicted)
Flash Point	215.876°C
Solubility	Chloroform (Sparingly), DMSO, Ethyl Acetate
Vapor Presure	0mmHg at 25°C
Appearance	Solid
Color	White to Off-White
pKa	13.06±0.40(Predicted)
Storage Condition	Sealed in dry,Room Temperature
Refractive Index	1.609

147128-77-6 - Introduction

(4S,6S)-4H-Thieno[2,3-b]-thiopyran-4-ol-5,6-dihydro-6-methyl-7,7-dioxide is an organic compound with the chemical formula C10H16N2O and the structural formula (CH3)2NC6H3NH2. It is a colorless liquid with a special ammonia smell. The following is a description of the properties, uses, preparation and safety information of (4S,6S)-4H-Thieno[2,3-b]-thiopyran-4-ol-5, 6-dihydro-6-methyll-7, 7-dioxide:

Nature:
- (4S,6S)-4H-Thieno[2,3-b]-thiopyran-4-ol-5,6-dihydro-6-methyl-7,7-dioxide is soluble in organic solvents such as water, alcohols and ethers.
-It is alkaline and can react with acids to form salts.
- (4S,6S)-4H-Thieno[2,3-b]-thiopyran-4-ol-5, 6-dihydro-6-methyll-7, 7-dioxide will decompose and release toxic gases at high temperatures.

Use:
- (4S,6S)-4H-Thieno[2,3-b]-thiopyran-4-ol-5, 6-dihydro-6-methyll-7, 7-dioxide is an important organic synthesis intermediate, widely used in pesticides, medicine and dyes and other fields.
-It can be used as an oxidant, reductant and catalyst component.

Method:
- (4S,6S)-4H-Thieno[2,3-b]-thiopyran-4-ol-5,6-dihydro-6-methyl-7,7-dioxide can be obtained by oxidizing benzylamine with formaldehyde. First, under alkaline conditions, benzylamine and formaldehyde undergo a condensation reaction to produce dorzolamide, and then (4S,6S)-4H-Thieno[2,3-b]-thiopyran-4-ol-5,6-dihydro-6-methyl-7 are obtained by a dehydrogenation reaction, 7-dioxide.

Safety Information:
- (4S,6S)-4H-Thieno[2,3-b]-thiopyran-4-ol-5, 6-dihydro-6-methyll-7, 7-dioxide is a toxic substance that may cause harm to humans and the environment.
-Wear protective glasses, gloves and protective clothing when using (4S,6S)-4H-Thieno[2,3-b]-thiopyran-4-ol-5, 6-dihydro-6-methyll-7, 7-dioxide, ensure a well-ventilated operating environment.
-Avoid inhalation of (4S,6S)-4H-Thieno[2,3-b]-thiopyran-4-ol-5,6-dihydro -6-methyll-7, 7-dioxide gas and skin contact. If contact occurs, rinse immediately with plenty of water and seek medical help.
- (4S,6S)-4H-Thieno[2,3-b]-thiopyran-4-ol-5, 6-dihydro-6-methyll-7, 7-dioxide should be stored and used away from flammable substances such as fire sources, heat sources and oxidants.

Last Update：2024-04-09 21:01:54