148849-67-6
Ivabradine hydrochloride
CAS: 148849-67-6
Molecular Formula: C27H36N2O5.HCl
148849-67-6 - Names and Identifiers
| Name | Ivabradine hydrochloride |
| Synonyms | Corlentor Ivabradine HCl Ivabradine hydrochloride IVABRADINE HYDROCHLORIDE-OTHER COMPOUNDSCONTAINING AN UNFUSED PYRAZOLE RING(WHETHER OR NOT HYDROGENATED)IN THE STRUCTUR 3-[3-[[(8S)-3,4-Dimethoxy-8-bicyclo[4.2.0]octa-1,3,5-trienyl]methyl-methylamino]propyl]-7,8-dimethoxy-2,5-dihydro-1H-3-benzazepin-4-one hydrochloride 3-[3-[[[(7S)-3,4-Dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl]methylamino]propyl]-1,3,4,5-tetrahydro-7,8-dimethoxy-2H-3-benzazepin-2-one Hydrochloride 3-{3-[{[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl}(methyl)amino]propyl}-7,8-dimethoxy-1,3,4,5-tetrahydro-2H-3-benzazepin-2-one hydrochloride |
| CAS | 148849-67-6 |
| EINECS | 638-798-3 |
| InChI | InChI=1/C27H36N2O5.ClH/c1-28(17-21-11-20-14-25(33-4)26(34-5)16-22(20)21)8-6-9-29-10-7-18-12-23(31-2)24(32-3)13-19(18)15-27(29)30;/h12-14,16,21H,6-11,15,17H2,1-5H3;1H/t21-;/m1./s1 |
| InChIKey | HLUKNZUABFFNQS-ZMBIFBSDSA-N |
148849-67-6 - Physico-chemical Properties
| Molecular Formula | C27H36N2O5.HCl |
| Molar Mass | 505.05 |
| Melting Point | 193-196?C |
| Boling Point | 626.9°C at 760 mmHg |
| Specific Rotation(α) | 58921 +7.8°; 36521 +27.8° (c = 1% in DMSO) |
| Flash Point | 332.9°C |
| Solubility | DMSO 101 mg/mL (199.98 mM);Water 82 mg/mL (162.36 mM);Ethanol 101 mg/mL (199.98 mM) |
| Vapor Presure | 1.24E-15mmHg at 25°C |
| Appearance | powder |
| Color | white to beige |
| Merck | 14,5247 |
| Storage Condition | 2-8°C |
| MDL | MFCD00929899 |
| In vivo study | Ivabradine hydrochloride treatment (10 mg/kg/d) induces long-term HRR, and that improves diastolic LV function probably involving attenuated hypoxia, reduced remodeling, and/or preserved nitric oxide bioavailability, resulting from processes triggered early after HRR initiation: angiogenesis and/or preservation of endothelial nitric oxide synthase expression. Ivabradine hydrochloride leads to a sustained 15-20% heart rate reduction, but has no effect on blood pressure. While ivabradine has no effect on endothelial function and vascular reactive oxygen species production in angiotensin II-treated rats, it improves both parameters in ApoE knockout mice. Ivabradine hydrochloride treatment leads to an attenuation of angiotensin II signaling and increased the expression of telomere-stabilizing proteins in ApoE knockout mice, which may explain its beneficial effects on the vasculature. The absence of these protective ivabradine effects in angiotensin II-infused rats may relate to the treatment duration or the presence of arterial hypertension. |
148849-67-6 - Risk and Safety
| Hazard Symbols | N - Dangerous for the environment |
| Risk Codes | 50/53 - Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. |
| Safety Description | S60 - This material and its container must be disposed of as hazardous waste. S61 - Avoid release to the environment. Refer to special instructions / safety data sheets. |
| UN IDs | UN 3077 9 / PGIII |
| WGK Germany | 3 |
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