150417-90-6
GC7 Sulfate
CAS: 150417-90-6
Molecular Formula: C8H22N4O4S
150417-90-6 - Names and Identifiers
| Name | GC7 Sulfate |
| Synonyms | GC7 Sulfate |
| CAS | 150417-90-6 |
150417-90-6 - Physico-chemical Properties
| Molecular Formula | C8H22N4O4S |
| Molar Mass | 270.35 |
| Storage Condition | Room Temprature |
| In vitro study | The treatment of MYCN2 (±Dox) and BE(2)-C cells with GC7 Sulfate for 72 h at various concentrations (0.1 to 100 μM) significantly reduces the number of viable cells in a dose-dependent manner. In MYCN2 cells, 5 μM of GC7 Sulfate inhibits cell viability by ~40 and ~60 %, respectively, compare to untreated control cells. BE(2)-C cells require 25 μM of GC7 Sulfate to reduce cell viability by ~50 %. Exposure to 10 and 100 μM GC7 for 72 h clearly decreases the levels of total retinoblastoma (Rb) and phosphorylated Rb as well as of Cdk4 protein, and increases the levels of p21 protein. Between 0 and 20 μM, GC7 Sulfate induces little cytotoxicity in HCC cells, while higher concentrations of GC7 Sulfate (50 to 100 μM) significantly inhibit the viability of all five HCC cell lines tested. Newly synthesized 3 H-labeled hypusine of eIF5A1/eIF5A2 is rarely detected after 20 μM GC7 Sulfate treatment, compare to untreated control. The activity of [ 3 H]-spermidine incorporated into HCC cells is significantly decreased by 20 μM GC7 Sulfate or higher concentration. |
150417-90-6 - Introduction
GC7 Sulfate is an organic compound known chemically as [(1S,2S)-2-Methyl-1,2-dihydro-1-((1R)-1-methylpropyl)-3H-imidazole-4-
boxamido](4-methylphenylsulfonyl)-L-leucine sulfate. It is a white solid.
GC7 Sulfate is widely used as a protein inhibitor in biochemistry, especially in the field of peptide prolination modification research and anti-tumor therapy. It inhibits cell proliferation and tumor growth by inhibiting protein post-translational modifying enzymes such as prolinase and peptidase.
The preparation method of GC7 Sulfate is through chemical synthesis. First, the main structural unit is synthesized, and then sulfuric acid is added to react to generate GC7 Sulfate.
Regarding safety information, GC7 Sulfate is a laboratory chemical that may be hazardous to human health. During use, wear appropriate personal protective equipment, such as lab gloves, face mask and goggles, to prevent contact with skin, eyes or inhalation of splashes. During storage, it should be kept away from fire and flame, and kept in a sealed container to avoid mixing with other chemicals. During the handling process, correct laboratory operating procedures should be followed, and safe handling and disposal should be carried out in accordance with relevant regulations.
boxamido](4-methylphenylsulfonyl)-L-leucine sulfate. It is a white solid.
GC7 Sulfate is widely used as a protein inhibitor in biochemistry, especially in the field of peptide prolination modification research and anti-tumor therapy. It inhibits cell proliferation and tumor growth by inhibiting protein post-translational modifying enzymes such as prolinase and peptidase.
The preparation method of GC7 Sulfate is through chemical synthesis. First, the main structural unit is synthesized, and then sulfuric acid is added to react to generate GC7 Sulfate.
Regarding safety information, GC7 Sulfate is a laboratory chemical that may be hazardous to human health. During use, wear appropriate personal protective equipment, such as lab gloves, face mask and goggles, to prevent contact with skin, eyes or inhalation of splashes. During storage, it should be kept away from fire and flame, and kept in a sealed container to avoid mixing with other chemicals. During the handling process, correct laboratory operating procedures should be followed, and safe handling and disposal should be carried out in accordance with relevant regulations.
Last Update：2024-04-09 20:02:46
Supplier List
Product Name: GC7 Sulfate Visit Supplier Webpage Request for quotation
CAS: 150417-90-6
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
CAS: 150417-90-6
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Product Name: GC7 Sulfate Visit Supplier Webpage Request for quotation
CAS: 150417-90-6
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
CAS: 150417-90-6
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
View History