150736-71-3

150736-71-3 - Names and Identifiers

Name	Carbamic acid, [(1R)-1-(hydroxymethyl)propyl]-, 1,1-dimethylethyl ester
Synonyms	(R)-TERT-BUTYL (1-HYDROXYBUTAN-2-YL)CARBAMATE tert-Butyl (R)-(1-hydroxybutan-2-yl)carbamate Carbamic acid, [(1R)-1-(hydroxymethyl)propyl]-, 1,1-dimethylethyl ester Carbamic acid,N-[(1R)-1-(hydroxymethyl)propyl]-, 1,1-dimethylethyl ester Carbamic acid, [(1R)-1-(hydroxymethyl)propyl]-, 1,1-dimethylethyl ester (9CI)
CAS	150736-71-3

150736-71-3 - Physico-chemical Properties

Molecular Formula	C9H19NO3
Molar Mass	189.25
Melting Point	40-45°C
Storage Condition	Room Temprature

150736-71-3 - Risk and Safety

Hazard Symbols	C - Corrosive
Risk Codes	R22 - Harmful if swallowed R34 - Causes burns
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
UN IDs	UN 2923 6.1(8) / PGIII
WGK Germany	1

150736-71-3 - Introduction

Carbamic acid, [(1R)-1-(hydroxymethyl)propyl]-, 1,1-dimethyl ester is an organic compound whose full name is N-tert-Butyl-(R)-2-amino-1-butanol. Its properties are as follows:

1. Appearance: colorless to light yellow liquid.
2. Solubility: Soluble in many organic solvents, such as ether, alcohol and ketone.
3. Melting point and boiling point: The melting point of the compound is -29 ℃, and the boiling point is 168-170 ℃.

Carbamic acid, [(1R)-1-(hydroxymethyl)propyl]-, 1,1-dimethylethyl ester has a wide range of applications in organic synthesis, mainly used in the synthesis of chiral molecules and pharmaceutical intermediates. It can be used as a precursor of chiral selective catalyst, can carry out esterification, acylation, amination and other reactions, and has an important role in the synthesis of biologically active compounds.

For the preparation of Carbamic acid, [(1R)-1-(hydroxymethyl)propyl]-, 1,1-dimethyl ester, the synthesis can be carried out through the following steps: First, 2-Butenoic acid reacts with N-tert-butoxycarbonic acid (N-Boc-OXALYL CHLORIDE) to give 2-butenyl-N-Boc-tert-butoxycarbamide. This compound is then hydrogenated with hydrogen in the presence of a suitable catalyst to produce Carbamic acid, [(1R)-1-(hydroxymethyl) prodrug]-, 1,1-dimethylethyyl ester.

When using or handling Carbamic acid, [(1R)-1-(hydroxymethyl)propyl]-, 1,1-dimethyl ester, the following safety precautions should be taken:
1. Need to operate in a well-ventilated laboratory, avoid inhalation of gas or vapor.
2. Wear appropriate personal protective equipment, such as gloves and goggles, to avoid skin and eye contact.
3. Avoid contact with strong oxidants, strong acids and strong bases to avoid dangerous reactions.
4. Waste needs to be disposed of properly and in compliance with local laws and regulations.

Last Update：2024-04-09 21:01:54