151098-17-8
Ethyl 5-pyridin-3-yl-1,2,4-oxadiazole-3-carboxylate
CAS: 151098-17-8
Molecular Formula: C10H9N3O3
151098-17-8 - Names and Identifiers
| Name | Ethyl 5-pyridin-3-yl-1,2,4-oxadiazole-3-carboxylate |
| Synonyms | Ethyl 5-pyridin-3-yl-1,2,4-oxadiazole-3-carboxylate 1,2,4-Oxadiazole-3-carboxylic acid, 5-(3-pyridinyl)-, ethyl ester |
| CAS | 151098-17-8 |
151098-17-8 - Physico-chemical Properties
| Molecular Formula | C10H9N3O3 |
| Molar Mass | 219.2 |
| Density | 1.277±0.06 g/cm3(Predicted) |
| Boling Point | 371.2±44.0 °C(Predicted) |
| pKa | 1.65±0.12(Predicted) |
| Sensitive | IRRITANT |
| MDL | MFCD09991790 |
151098-17-8 - Introduction
Ethyl 5-pyridin-3-yl-1,2,4-oxadiazole-3-carboxylate is an organic compound with the chemical formula C12H10N4O3. It has the following properties:
1. Appearance: colorless to light yellow crystal or crystalline powder.
2. Solubility: Soluble in some organic solvents, such as alcohols, ethers and chlorinated hydrocarbons.
3. melting point: about 80-85 degrees Celsius.
Ethyl 5-pyridin-3-yl-1,2,4-oxadiazole-3-carboxylate has certain uses in the field of drugs and pesticides. It is widely used as an intermediate in organic synthesis and can be used to prepare biologically active compounds, such as antibacterial drugs and pesticides.
The preparation method of the compound can be achieved by the following steps:
1.5-pyridine acetic acid and dichloroformic acid are added to the sodium hydroxide solution for reaction to generate 5-pyridine acetic acid sodium salt.
2. in methyl chloride, the sodium salt generated in the previous step is reacted with cuprous cyanide to obtain the corresponding halide.
3. the halide reacts with excess ammonia and cuprous cyanide at high temperature to generate Ethyl 5-pyridin-3-yl-1,2,4-oxadiazole-3-carboxylate.
Regarding the safety information of this compound, the following points need to be paid close attention:
1. The compound may be irritating to the eyes, skin and respiratory system, so appropriate protective equipment should be worn during use or operation.
2. Avoid contact with strong oxidants and strong acids to avoid danger.
3. When storing and carrying, store it in a sealed container, away from fire and high temperature conditions.
4. When used in a laboratory environment, it should be operated in accordance with the correct operating procedures and safe operating measures to avoid danger.
1. Appearance: colorless to light yellow crystal or crystalline powder.
2. Solubility: Soluble in some organic solvents, such as alcohols, ethers and chlorinated hydrocarbons.
3. melting point: about 80-85 degrees Celsius.
Ethyl 5-pyridin-3-yl-1,2,4-oxadiazole-3-carboxylate has certain uses in the field of drugs and pesticides. It is widely used as an intermediate in organic synthesis and can be used to prepare biologically active compounds, such as antibacterial drugs and pesticides.
The preparation method of the compound can be achieved by the following steps:
1.5-pyridine acetic acid and dichloroformic acid are added to the sodium hydroxide solution for reaction to generate 5-pyridine acetic acid sodium salt.
2. in methyl chloride, the sodium salt generated in the previous step is reacted with cuprous cyanide to obtain the corresponding halide.
3. the halide reacts with excess ammonia and cuprous cyanide at high temperature to generate Ethyl 5-pyridin-3-yl-1,2,4-oxadiazole-3-carboxylate.
Regarding the safety information of this compound, the following points need to be paid close attention:
1. The compound may be irritating to the eyes, skin and respiratory system, so appropriate protective equipment should be worn during use or operation.
2. Avoid contact with strong oxidants and strong acids to avoid danger.
3. When storing and carrying, store it in a sealed container, away from fire and high temperature conditions.
4. When used in a laboratory environment, it should be operated in accordance with the correct operating procedures and safe operating measures to avoid danger.
Last Update：2024-04-09 21:54:55
