151213-16-0
BAY-Y 3118
CAS: 151213-16-0
Molecular Formula: C20H21ClFN3O3
151213-16-0 - Names and Identifiers
| Name | BAY-Y 3118 |
| Synonyms | BAY-Y 3118 151213-16-0 |
| CAS | 151213-16-0 |
151213-16-0 - Physico-chemical Properties
| Molecular Formula | C20H21ClFN3O3 |
| Molar Mass | 405.85 |
| Solubility | DMSO |
| Storage Condition | -20℃ |
| In vitro study | BAY-Y 3118 is potent against Haemophilhs influenzae, Moraxela catarrhalis, Acinetobacter baumannii, Xanthomonas maltophiia, gram-positive cocci , and anaerobes; MICs for 50%o of the strains (MIC 50 s) and MIC 90 s are ≤0.015 and ≤0.015, ≤0.015 and ≤0.015, 0.03 and 2, 0.25 and 0.5, 0.06 and 1, and 0.12 and 0.25 μg/mL, respectively. The cellular concentration-to-extracellular concentration ratio of BAY-Y 3118 is higher than 6.3 at extracellular concentrations ranging from 2 to 100 mg/L. The uptake of BAY-Y 3118 is rapid, reversible and nonsaturable. The intracellular penetration of BAY-Y 3118 is significantly affected by environmental temperature and cell viability. BAY-Y 3118 reaches high intracellular concentrations within human polymorphonuclear leukocytes (PMNs) and remains active intracellularly. All strains of L. monocytogenes and other Listeria spp. are highly susceptible; the MICs for these organisms ranges from 0.062 to 0.25 μg/mL. BAY-Y 3118 is rapidly bactericidal in vitro , with a postantibiotic effect occurring for 3 h after removal of the antibiotic. L. monocytogenes is eliminated from infected L929 cells treated with BAY-Y 3118, suggesting a bactericidal effect on the listeriae in these cells. |
| In vivo study | Immunocompetent mice are rapidly cured by treatment with 4 mg every 12 h. Concomitantly, the levels of interleukin 6 and gamma interferon in mouse sera decline rapidly. In immunocompetent mice, treatment with 2 mg of BAY-Y 3118 every 12 h results in a greater initial reduction in the listerial counts in the organs than treatment with 2 mg of ampicillin every 12 h. BAY-Y 3118 completely eliminates L. monocytogenes from the livers and spleens of chronically infected nude mice. |
151213-16-0 - Introduction
BAY-Y 3118 is a chemical substance whose chemical name is 2-Ethoxyethyl N-(2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)phenyl) carbamate. The following is a description of the nature, use, preparation and safety information of BAY-Y 3118:
Nature:
1. Appearance: BAY-Y 3118 is colorless to light yellow solid.
2. Solubility: BAY-Y 3118 is soluble in some organic solvents, such as ethanol and dimethylformamide.
3. Melting Point: the melting point of BAY-Y 3118 is about 120-125 ℃.
Use:
BAY-Y 3118 is commonly used in the process of organic synthesis, especially in the preparation of synthetic drugs and pesticides. It can be used as an important intermediate for the preparation of other compounds, such as organometallic complexes.
Preparation Method:
The preparation method of BAY-Y 3118 includes the following steps:
1. Reaction of 2-Ethoxyethyl carbamate with 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl bromide to generate the corresponding compound.
2. The above product is reacted with diphenylamine to produce the target product BAY-Y 3118.
Safety Information:
1. BAY-Y 3118 need to be stored in a dry, cool place, away from fire and oxidant.
2. When using the BAY-Y 3118, you should wear appropriate protective equipment, such as protective glasses and gloves.
3. Avoid inhalation, ingestion or contact with skin. If accidental contact occurs, wash the affected area immediately with plenty of water and seek medical help.
4. BAY-Y 3118 may be harmful to the environment and should be avoided from being discharged into water or soil.
Note: The above information is for reference only. Please fully understand and comply with relevant safety operation procedures when using the BAY-Y 3118, and follow local laws and regulations.
Nature:
1. Appearance: BAY-Y 3118 is colorless to light yellow solid.
2. Solubility: BAY-Y 3118 is soluble in some organic solvents, such as ethanol and dimethylformamide.
3. Melting Point: the melting point of BAY-Y 3118 is about 120-125 ℃.
Use:
BAY-Y 3118 is commonly used in the process of organic synthesis, especially in the preparation of synthetic drugs and pesticides. It can be used as an important intermediate for the preparation of other compounds, such as organometallic complexes.
Preparation Method:
The preparation method of BAY-Y 3118 includes the following steps:
1. Reaction of 2-Ethoxyethyl carbamate with 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl bromide to generate the corresponding compound.
2. The above product is reacted with diphenylamine to produce the target product BAY-Y 3118.
Safety Information:
1. BAY-Y 3118 need to be stored in a dry, cool place, away from fire and oxidant.
2. When using the BAY-Y 3118, you should wear appropriate protective equipment, such as protective glasses and gloves.
3. Avoid inhalation, ingestion or contact with skin. If accidental contact occurs, wash the affected area immediately with plenty of water and seek medical help.
4. BAY-Y 3118 may be harmful to the environment and should be avoided from being discharged into water or soil.
Note: The above information is for reference only. Please fully understand and comply with relevant safety operation procedures when using the BAY-Y 3118, and follow local laws and regulations.
Last Update：2024-04-09 15:16:35
Supplier List
Product Name: BAY-Y 3118 Visit Supplier Webpage Request for quotation
CAS: 151213-16-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
CAS: 151213-16-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Product Name: BAY-Y 3118 Visit Supplier Webpage Request for quotation
CAS: 151213-16-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
CAS: 151213-16-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
View History