Molecular Formula | C4H9Br2NO2 |
Molar Mass | 262.93 |
Melting Point | 189°C (dec.)(lit.) |
Boling Point | 294.5°C at 760 mmHg |
Specific Rotation(α) | 13 º (589nm, c=1, H2O) |
Flash Point | 131.9°C |
Solubility | DMF (Slightly), DMSO, Methanol (Slightly) |
Vapor Presure | 0.000395mmHg at 25°C |
Appearance | White crystalline powder |
Color | White to Light Brown |
Storage Condition | Inert atmosphere,Room Temperature |
Stability | Unstable in Solution, Moisture Sensitive, Hygroscopic |
Refractive Index | 17 ° (C=1, MeOH) |
MDL | MFCD01631290 |
Hazard Symbols | Xi - Irritant![]() |
Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
WGK Germany | 3 |
introduction | l (+)-2-amino -4-bromobutyric acid hydrobromide is in white crystalline powder form and can be used as an intermediate in pharmaceutical synthesis for pharmaceutical synthesis and experimental research. |
Use | L ()-2-amino-4-bromobutyric acid hydrobromide is an important intermediate for the chemical synthesis of SAM and its nitrogen analogs, and can also be used to prepare L-selenomethionine and some precursors of unnatural amino acids, among them, L-selenomethionine plays an important role in selenoprotein and has anti-cancer effect, so it has attracted much attention. |
synthesis method | in 100 mL sealed pipe, weigh 1.19g of homoserine (10mmol), add 16 mL of 33% hydrogen bromide acetic acid solution, and react in an oil bath pan at 75 ℃ for 6 hours. Cool to room temperature, concentrate under reduced pressure, remove excess acid, and obtain the crude product of compound L ()-2-amino-4-bromobutyric acid hydrobromide. Ethyl acetate extraction (3 × 10 mL). The organic layers were combined, dried with anhydrous sodium sulfate, filtered, and the solvent was spun. The crude product was separated and purified through a chromatography column. The eluent was Hex/EA(v/v = 1:1) to obtain compound L(+)-2-amino-4-bromobutyric acid hydrobromide. The product is a white crystalline powder. |