153436-54-5
PD153035
CAS: 153436-54-5
Molecular Formula: C16H14BrN3O2
153436-54-5 - Names and Identifiers
153436-54-5 - Physico-chemical Properties
| Molecular Formula | C16H14BrN3O2 |
| Molar Mass | 360.21 |
| Density | 1.499±0.06 g/cm3(Predicted) |
| Melting Point | 189-190 °C |
| Boling Point | 472.1±45.0 °C(Predicted) |
| Solubility | Soluble in DMSO (up to 5 mg/ml). |
| Appearance | White to off-white solid. |
| Color | White or off-white |
| pKa | 5.55±0.30(Predicted) |
| Storage Condition | Keep in dark place,Inert atmosphere,2-8°C |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months. |
| In vitro study | PD153035 (SU 5271) inhibits EGF-stimulated receptor autophosphorylation in A431 human epidermoid carcinoma cells, with an IC 50 of 14 nM. PD153035 (SU 5271) has little effect on PDGFR, FGFR, CSF-1 receptor, the insulin receptor, or on src tyrosine kinases at concentrations as high as 50 μM. PD153035 (SU 5271) rapidly suppresses autophosphorylation of the EGF receptor at low nanomolar concentrations in fibroblasts or in human epidermoid carcinoma cells and selectively blocks EGF-mediated cellular processes including mitogenesis, early gene expression, and oncogenic transformation. PD153035 (SU 5271) causes a dose-dependent growth inhibition of EGF receptor-positive cell lines, beginning at less than micromolar concentrations, and the IC 50 is less than 1 pM in most cases. |
| In vivo study | PD153035 (SU 5271) levels in the plasma and tumor rise to 50 and 22 μM within 15 minutes following a single i.p. dose of 80 mg/kg. While the plasma levels of PD153035 (SU 5271) falls below 1 μM by 3 hours, in the tumors it remains at micromolar concentrations for at least 12 hours. The tyrosine phosphorylation of the EGF receptor is rapidly suppressed by 80-90% in the tumors. |
153436-54-5 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.776 ml | 13.881 ml | 27.762 ml |
| 5 mM | 0.555 ml | 2.776 ml | 5.552 ml |
| 10 mM | 0.278 ml | 1.388 ml | 2.776 ml |
| 5 mM | 0.056 ml | 0.278 ml | 0.555 ml |
Last Update：2024-01-02 23:10:35
153436-54-5 - Reference Information
| biological activity | PD153035 is a specific, potent EGFR inhibitor with a Ki of 5.2 pM. |
| Target | Value |
| EGFR (Cell-free assay) | 5.2 pM(Ki) |
Last Update：2024-04-09 20:52:54
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Spot supply
Product Name: PD153035 Visit Supplier Webpage Request for quotationCAS: 153436-54-5
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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