1536200-31-3
GNE-9605
CAS: 1536200-31-3
Molecular Formula: C17H20ClF4N7O
1536200-31-3 - Names and Identifiers
1536200-31-3 - Physico-chemical Properties
| Molecular Formula | C17H20ClF4N7O |
| Molar Mass | 449.83 |
| Density | 1.67±0.1 g/cm3(Predicted) |
| Boling Point | 587.9±60.0 °C(Predicted) |
| Solubility | DMSO: ≥ 60 mg/mL |
| pKa | 5.04±0.60(Predicted) |
| Storage Condition | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
| In vitro study | GNE-9605 was highly effective against LRRK2 in both biochemical (Ki = 2.0 nM) and cellular (IC50=19 nM) assays. Of the in vitro human MDR1 permeability data, GNE-9605 showed good brain permeability in higher species. |
| In vivo study | In vivo rat PK studies showed that GNE-9605 (1 mg/kg, p.o.) with a total plasma clearance of 26 mL/min/kg and good oral bioactivity (90%). In G2019S Parkinson's disease mutant BAC transgenic mice expressing human LRRK2 protein, GNE-9605 (10 and 50 mg/kg, I. p.) inhibited LRRK2 Ser1292 autophosphorylation in vivo. |
1536200-31-3 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.223 ml | 11.115 ml | 22.23 ml |
| 5 mM | 0.445 ml | 2.223 ml | 4.446 ml |
| 10 mM | 0.222 ml | 1.112 ml | 2.223 ml |
| 5 mM | 0.044 ml | 0.222 ml | 0.445 ml |
Last Update：2024-01-02 23:10:35
1536200-31-3 - Introduction
GNE-9605 is a chemical that is also known as GNE9605. The following is a description of the nature, use, preparation and safety information of the GNE-9605:
Properties: GNE-9605 is a solid compound with a chemical structure of C23H22N2O3. It had the appearance of a white crystalline powder. GNE-9605 is a selective monoamine oxidase B(MAO-B) inhibitor.
Purpose: GNE-9605 are commonly used in research and laboratory applications. It is widely used to study the role and regulation of MAO-B, as well as the biological effects related to tumors and neurodegenerative diseases. Due to its MAO-B inhibitor properties, GNE-9605 may also have potential applications in the treatment of certain diseases.
preparation method: the preparation method of the GNE-9605 has not yet been made public. It may be synthesized by chemical synthesis, but the specific preparation route and method are still trade secrets.
Safety Information: Because GNE-9605 is a laboratory chemical, safety and toxicity data may be limited. Appropriate laboratory safety practices need to be followed when operating the GNE-9605. It is recommended to conduct a comprehensive risk assessment before use and take necessary protective measures, such as wearing protective glasses, gloves and laboratory coats. If swallowing, inhalation or skin contact with GNE-9605 occurs, seek medical help immediately and deal with it according to the doctor's instructions.
Please note that the information provided above is based on general understanding, and specific details and research progress may require further reference and verification.
Properties: GNE-9605 is a solid compound with a chemical structure of C23H22N2O3. It had the appearance of a white crystalline powder. GNE-9605 is a selective monoamine oxidase B(MAO-B) inhibitor.
Purpose: GNE-9605 are commonly used in research and laboratory applications. It is widely used to study the role and regulation of MAO-B, as well as the biological effects related to tumors and neurodegenerative diseases. Due to its MAO-B inhibitor properties, GNE-9605 may also have potential applications in the treatment of certain diseases.
preparation method: the preparation method of the GNE-9605 has not yet been made public. It may be synthesized by chemical synthesis, but the specific preparation route and method are still trade secrets.
Safety Information: Because GNE-9605 is a laboratory chemical, safety and toxicity data may be limited. Appropriate laboratory safety practices need to be followed when operating the GNE-9605. It is recommended to conduct a comprehensive risk assessment before use and take necessary protective measures, such as wearing protective glasses, gloves and laboratory coats. If swallowing, inhalation or skin contact with GNE-9605 occurs, seek medical help immediately and deal with it according to the doctor's instructions.
Please note that the information provided above is based on general understanding, and specific details and research progress may require further reference and verification.
Last Update：2024-04-09 21:04:16
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Spot supply
Product Name: GNE-9605 Visit Supplier Webpage Request for quotationCAS: 1536200-31-3
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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