154476-57-0
N,N'-Bis(tert-butoxycarbonyl)guanidine
CAS: 154476-57-0
Molecular Formula: C11H21N3O4
154476-57-0 - Names and Identifiers
| Name | N,N'-Bis(tert-butoxycarbonyl)guanidine |
| Synonyms | Di-Boc-Guanidine N,N'-DI(TERT-BUTOXYCARBONYL)GUANIDINE N,N'-Bis(tert-butoxycarbonyl)guanidine 1,3-Bis(Tert-butyoxycarbonyl)guanidine tert-butyl N-({[(tert-butoxy)carbonyl]amino}methanimidoyl)carbamate Carbamic acid, N,N'-(carbonimidoyl)bis-, C,C'-bis(1,1-dimethylethyl) ester |
| CAS | 154476-57-0 |
154476-57-0 - Physico-chemical Properties
| Molecular Formula | C11H21N3O4 |
| Molar Mass | 259.3 |
| Density | 1.13±0.1 g/cm3(Predicted) |
| Melting Point | 141-144°C(lit.) |
| pKa | 8.24±0.46(Predicted) |
| Storage Condition | Keep in dark place,Sealed in dry,Room Temperature |
154476-57-0 - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
154476-57-0 - Introduction
1,3-bis (tert-butoxycarbonyl)guanidine, also known as bis-Boc guanidine or N,N'-Bis(tert-butoxycarbonyl)guanidine, is an organic compound. The following is a description of the nature, use, preparation and safety information of bis-Boc guanidine:
Nature:
-Appearance: Bis-Boc guanidine is usually a white crystalline solid.
-Solubility: It can be dissolved in common organic solvents, such as ether, methanol and ethyl acetate.
Use:
-Protecting group in chemical synthesis: bis-Boc guanidine can be used as a protecting group in chemical synthesis, which can protect the amino functional group so that it is not affected under the reaction conditions, and it is easy to remove the protecting group when needed. This makes bis-Boc guanidine has important application value in organic synthesis.
-Pharmaceutical research: Bis-Boc guanidine is an important intermediate, which is widely used in many fields of pharmaceutical research and synthesis, such as the synthesis of peptide compounds, spirocyclic compounds and natural products.
Preparation Method:
The preparation method of bis-Boc guanidine is as follows:
1. At low temperature, the carbamate is reacted with silver pentachlorate to obtain the corresponding silver ammonia salt.
2. A silver ammonia salt is reacted with tert-butoxycarbonyl chloride to obtain bis-Boc guanidine in the presence of a base.
Safety Information:
-Boc guanidine is less toxic, but the compound should still be handled and used in accordance with laboratory safety practices.
-When handling or handling bis-Boc guanidine, you need to wear personal protective equipment, such as laboratory gloves, goggles and lab clothes.
-The compound should be stored in a dry, ventilated place, away from fire and oxidizing agents.
This is an introduction to the properties, uses, preparation and safety information of 1,3-di (tert-butoxycarbonyl) guanidine.
Nature:
-Appearance: Bis-Boc guanidine is usually a white crystalline solid.
-Solubility: It can be dissolved in common organic solvents, such as ether, methanol and ethyl acetate.
Use:
-Protecting group in chemical synthesis: bis-Boc guanidine can be used as a protecting group in chemical synthesis, which can protect the amino functional group so that it is not affected under the reaction conditions, and it is easy to remove the protecting group when needed. This makes bis-Boc guanidine has important application value in organic synthesis.
-Pharmaceutical research: Bis-Boc guanidine is an important intermediate, which is widely used in many fields of pharmaceutical research and synthesis, such as the synthesis of peptide compounds, spirocyclic compounds and natural products.
Preparation Method:
The preparation method of bis-Boc guanidine is as follows:
1. At low temperature, the carbamate is reacted with silver pentachlorate to obtain the corresponding silver ammonia salt.
2. A silver ammonia salt is reacted with tert-butoxycarbonyl chloride to obtain bis-Boc guanidine in the presence of a base.
Safety Information:
-Boc guanidine is less toxic, but the compound should still be handled and used in accordance with laboratory safety practices.
-When handling or handling bis-Boc guanidine, you need to wear personal protective equipment, such as laboratory gloves, goggles and lab clothes.
-The compound should be stored in a dry, ventilated place, away from fire and oxidizing agents.
This is an introduction to the properties, uses, preparation and safety information of 1,3-di (tert-butoxycarbonyl) guanidine.
Last Update：2024-04-09 02:00:49
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Product Name: N,N-di(Tert-Butoxycarbonyl) Guanidine Visit Supplier Webpage Request for quotationCAS: 154476-57-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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