1575-61-7
5-Chlorovaleryl chloride
CAS: 1575-61-7
Molecular Formula: C5H8Cl2O
1575-61-7 - Names and Identifiers
| Name | 5-Chlorovaleryl chloride |
| Synonyms | CVC 5-Chlorovaleryl 5-Chlorvalerylchlorid 5-chloro aMyl chloride 5-Chlorovaleryl chloride 5-Choropentanoyl chloride 5-Chlorovaleroyl chloride 5-Chloro valerate Chloride 5-chloropentanoyl chloride 5-CHLOROVALERYL CHLORIDE CVC 5-Chlorovaleric acid chloride |
| CAS | 1575-61-7 |
| EINECS | 216-403-1 |
| InChI | InChI=1/C5H8Cl2O/c6-4-2-1-3-5(7)8/h1-4H2 |
| InChIKey | SVNNWKWHLOJLOK-UHFFFAOYSA-N |
1575-61-7 - Physico-chemical Properties
| Molecular Formula | C5H8Cl2O |
| Molar Mass | 155.02 |
| Density | 1.206g/mLat 20°C |
| Boling Point | 38-39°C0.15mm Hg(lit.) |
| Flash Point | 195°F |
| Water Solubility | reacts |
| Vapor Presure | 0.586mmHg at 25°C |
| Appearance | Liquid |
| Specific Gravity | 1.200 |
| Color | Clear colorless to slightly yellow |
| BRN | 1745182 |
| Storage Condition | Store below +30°C. |
| Sensitive | Moisture Sensitive |
| Explosive Limit | 2.0-10.2%(V) |
| Refractive Index | n20/D 1.464(lit.) |
| Use | Organic reagents, pharmaceutical intermediates |
1575-61-7 - Risk and Safety
| Risk Codes | R22 - Harmful if swallowed R34 - Causes burns R23 - Toxic by inhalation R23/34 - |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| UN IDs | UN 3265 8/PG 2 |
| WGK Germany | 1 |
| RTECS | YV9108000 |
| FLUKA BRAND F CODES | 10-19-21 |
| HS Code | 29159000 |
| Hazard Class | 8 |
| Packing Group | III |
1575-61-7 - Reference Information
| Introduction | 5-chloropentanoyl chloride is an important intermediate in the synthesis of pyrazole herbicides. 5-chloropentanoyl chloride is used as the raw material of 1,1, 7-trichloro-1-hepten-3-one, and then the third generation pyrazole herbicide can be synthesized. Pyrazole herbicides have the characteristics of super efficient herbicidal activity, high selectivity, very low lactation toxicity and good environmental characteristics. In recent years, it is a hot spot in the research and development of herbicides in the world. With the increasing demand for highly effective herbicides, the demand for 5-chlorovaleryl chloride as an intermediate is also increasing. |
| Use | 5-chlorovaleryl chloride is a useful research chemical. |
| preparation | 3.5 δ-valerolactone (kmol) and 16kg of β-picoline (3-methylpyridine, 0.2kmol) were added to a 630L steel/glaze jar and heated to 120 °c. At 120 °c, the introduction of gaseous chloride at 1 m3/h was started and the temperature was further increased. Upon reaching 140 °c, additional introduction of gaseous phosgene was started, and a total of 3.84 of phosgene (kmol) was introduced over 24 hours. During the introduction, the temperature was increased to 145 °c. After the end of the phosgene addition, hydrogen chloride was added for post-reaction over the next 3 hours. The mixture was then cooled to 80 °c and excess phosgene was extracted with 2.5/hour of nitrogen for 12 hours. From the crude effluent, about 20L of the pre-run effluent was withdrawn at 1kPa abs(10mbar ABS) and an overhead temperature of 85 °c, and the remainder was then fractionated. There was thus obtained 440kg of 5-chloropentanoyl chloride (2.84kmol) with a purity of> 98GC area%, which corresponds to a yield of 81%. with the present process, chlorophosgene chlorides, in particular 5-chlorovaleryl chlorides and derivatives thereof, can be prepared in high yields and with a high purity of more than 98% by phosgenation of the corresponding lactones. |
| Application | 5-chloropentanoyl chloride is an acyl chloride organic substance, which can be used as an organic reagent and a pharmaceutical intermediate. |
Last Update：2024-04-09 02:00:04
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