15866-90-7

Name	Incyclinide
Synonyms	COL 3 CMT 3 Metastat NSC 683551 Incyclinide INCYCLINIDE (CMT-3, COL-3) 2-NaphthacenecarboxaMide,1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-,(4aS,5aR,12aS)-
CAS	15866-90-7

Molecular Formula	C19H17NO7
Molar Mass	371.34
Density	1.70±0.1 g/cm3(Predicted)
Melting Point	228-231 °C
Boling Point	752.8±60.0 °C(Predicted)
Solubility	10 mM in DMSO
pKa	4.50±1.00(Predicted)
Storage Condition	-20℃
In vitro study	Incyclinide has been shown to experimentally suppress prostate cancer, colon adenocarcinoma and melanoma invasiveness in cell culture. Adding incyclinide at final concentrations of 5 to 20 μM inhibits MT1-MMP gelatinolytic and caseinolytic activity, blocks MT1-MMPactivation of pro-MMP-2, and decreases invasiveness of HT-1080 fibrosarcoma cells. Incyclinide is an especially effective inhibitor of the growth and viability of filamentous fungi. Most of the MICs of CMT-3 against filamentous fungi are found to be between 0.25 and 8 μg/mL, and the inhibition of viability of these fungi by incyclinide is routinely higher than 90%.
In vivo study	Incyclinide inhibits tooth movement in the rat, probably by reducing the number of osteoclasts at the compression side. This might be due to induction of apoptosis in activated osteoclasts or reduced osteoclast migration. Reduced MMP activity by incyclinide might also directly inhibit degradation of the organic bone matrix.

Last Update：2024-01-02 23:10:35

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CAS: 15866-90-7
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15866-90-7

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