159275-17-9

159275-17-9 - Names and Identifiers

Name	benzyl 4-(bromomethyl)tetrahydro-1(2H)-pyridinecarboxylate
Synonyms	1-CBZ-4-(BROMOMETHYL)PIPERIDINE 4-(Bromomethyl)piperidine, N-CBZ protected benzyl 4-(bromomethyl)piperidine-1-carboxylate BENZYL 4-(BROMOMETHYL)PIPERIDINE-1-CARBOXYLATE N-(BENZYLOXYCARBONYL)-4-(BROMOMETHYL)PIPERIDINE N-(Benzyloxycarbonyl)-4-(bromomethyl)piperidine Benzyl 4-(bromoethyl)tetrahydro-1(2H)-pyridinecarboxylate BENZYL 4-(BROMOMETHYL)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE benzyl 4-(bromomethyl)tetrahydro-1(2H)-pyridinecarboxylate
CAS	159275-17-9
InChI	InChI=1/C14H18BrNO2/c15-10-12-6-8-16(9-7-12)14(17)18-11-13-4-2-1-3-5-13/h1-5,12H,6-11H2

159275-17-9 - Physico-chemical Properties

Molecular Formula	C14H18BrNO2
Molar Mass	312.2
Density	1.356g/cm³
Melting Point	68 °C
Boling Point	403.4°C at 760 mmHg
Flash Point	197.8°C
Vapor Presure	1.02E-06mmHg at 25°C
Storage Condition	2-8℃
Refractive Index	1.56

159275-17-9 - Risk and Safety

Risk Codes	R36/37/38 - Irritating to eyes, respiratory system and skin. R34 - Causes burns
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
Hazard Note	Irritant

159275-17-9 - Introduction

benzyl 4-(bromomethyl)tetrahydro-1(2H)-pyridinecarboxylate is an organic compound with the chemical formula C17H19BrNO2. Here is some basic information about benzyl 4-(bromomethyl)tetrahydro-1(2H)-pyridinecarboxylate:

Properties: benzyl 4-(bromomethyl)tetrahydro-1(2H)-pyridinecarboxylate is a white to off-white crystalline solid. It has low solubility and is soluble in organic solvents such as chloroform and dimethyl sulfoxide. It has a density of 1.39g/cm³ and a melting point of about 50-54°C.

Purpose: benzyl 4-(bromomethyl)tetrahydro-1(2H)-pyridinecarboxylate is an important organic synthesis intermediate. It is commonly used in drug synthesis, especially in the synthesis of S-1 (an anti-tumor drug).

preparation method: benzyl 4-(bromomethyl)tetrahydro-1(2H)-pyridinecarboxylate is usually prepared by the condensation reaction of benzyl alcohol and 4-cyanopiperidine to obtain the corresponding amide, benzyl 4-(aminomethyl) piperidinecarboxylate is then obtained by base-promoted hydrogenation. Finally, methyl bromide was used to replace the hydrogen atom on the amino group with a bromine atom to give the final product.

Safety Information: benzyl 4-(bromomethyl)tetrahydro-1(2H)-pyridinecarboxylate generally has low toxicity under normal conditions of use. However, when handling the substance, safety precautions are still required to avoid direct contact with the skin and inhalation of its dust or gas. If inhaled or ingested, seek medical help immediately.

Last Update：2024-04-09 21:00:56