159634-59-0

159634-59-0 - Names and Identifiers

Name	tert-butyl 3-oxo-2,3-dihydro-1'H-spiro[indene-1,4'-piperidine]-1'-carboxylate
Synonyms	Caboxylate N-BOC-1-[4-SPIRO-PIPERIDINE]-3-INDANONE 1'-Boc-3-oxo-2,3-dihydrospiro[indene-1,4'-piperidine] tert-butyl 3-oxo-2,3-dihydrospiro[indene-1,4'-piperidine]-1'-car tert-butyl 3-oxo-2,3-dihydrospiro[indene-1,4'-piperidine]-1'-caboxylate TERT-BUTYL 3-OXO-2,3-DIHYDROSPIRO[INDENE-1,4'-PIPERIDINE]-1'-CARBOXYLATE tert-butyl 3-oxo-2,3-dihydro-1'H-spiro[indene-1,4'-piperidine]-1'-carboxylate 2,3-Dihydro-3-oxo-spiro[1H-indene-1,4'-piperidine]-1'-carboxylic acid tert-butyl ester 2,3-dihydro-3-oxo-spiro[1H-indene-1,4'-piperidine]-1'-carboxylic acid 1,1-dimethylethyl ester Spiro[1H-indene-1,4'-piperidine]-1'-carboxylic acid, 2,3-dihydro-3-oxo- 1,1-diMethyl ethyl ester
CAS	159634-59-0
InChI	InChI=1/C18H23NO3/c1-17(2,3)22-16(21)19-10-8-18(9-11-19)12-15(20)13-6-4-5-7-14(13)18/h4-7H,8-12H2,1-3H3

159634-59-0 - Physico-chemical Properties

Molecular Formula	C18H23NO3
Molar Mass	301.38
Density	1.17
Melting Point	120-122 °C(Solv: ethyl acetate (141-78-6); ligroine (8032-32-4))
Boling Point	439.8±45.0 °C(Predicted)
Flash Point	219.8°C
Vapor Presure	6.18E-08mmHg at 25°C
pKa	-0.80±0.20(Predicted)
Storage Condition	Sealed in dry,Store in freezer, under -20°C
Refractive Index	1.57

159634-59-0 - Risk and Safety

Hazard Class

IRRITANT

159634-59-0 - Introduction

tert-butyl 3-oxo-2,3-dihydro-1 'H-spiro[indene-1,4'-piperidine]-1 '-carboxylate is a chemical substance with the following properties, uses, preparation and safety information:

Nature:
-Appearance: White to light yellow crystalline powder
-Molecular formula: C18H23NO3
-Molecular weight: 305.38g/mol
-Melting point: 98-100 ° C
-Boiling point: 358 ° C
-Solubility: Soluble in organic solvents such as ethanol, formamide and ethyl acetate

Use:
- tert-butyl 3-oxo-2,3-dihydro-1 'H-spiro[indene-1,4'-piperidine]-1 '-carboxylate is a drug intermediate, which is widely used in the field of medicine.
-It is often used to synthesize biologically active compounds, such as drugs with anti-inflammatory, antibacterial, and anti-tumor properties.

Method:
- tert-butyl 3-oxo-2,3-dihydro-1 'H-spiro[indene-1,4'-piperidine]-1 '-carboxylate can be prepared by chemical synthesis.
-The specific preparation method can be carried out by reacting indanone and piperidine first, then adding sodium dihydride and hydrogen peroxide, and then adding formyl chloride and tert-butyl alcohol for esterification reaction, and finally preparing the target product.

Safety Information:
- tert-butyl 3-oxo-2,3-dihydro-1 'H-spiro[indene-1,4'-piperidine]-1 '-carboxylate is a chemical substance that requires safety measures during handling and storage.
-It may be irritating to the eyes, skin and respiratory system, so wear protective gloves, goggles and a mask when using it.
-after treatment to be thoroughly cleaned and ventilated, avoid mixing with oxidants, strong acids and strong bases.
-If taken by mistake or inhaled, seek medical advice immediately and show the relevant safety data sheet.

Last Update：2024-04-09 20:49:11