Molecular Formula | C28H35NO3 |
Molar Mass | 433.58 |
Density | 1.20 |
Boling Point | 638.5±55.0 °C(Predicted) |
pKa | 12.94±0.60(Predicted) |
Storage Condition | Sealed in dry,Room Temperature |
In vivo study | Ulipristal (CDB 3236) may suppress the growth of uterine leiomyomatosis. By inhibiting or delaying ovulation and effecting endometrial tissue, ulipristal can be used as an emergency contraception. |
ulipristal acetate | ulipristal acetate is a new oral emergency contraceptive, it is the active chemical component of Ella, a new generation of emergency contraceptive currently available in the United States. It can not only be used within 120h after unprotected sexual intercourse in women, but also the efficacy of emergency contraception will not decrease with the delay of medication, and the safety and tolerability are very good. Compared with the most commonly used emergency contraceptive, levonorgestrel, ulipristal acetate has wider clinical applicability and has the potential to prevent more unwanted pregnancies. ulipristal acetate was developed by HRA Pharmaceuticals Inc. and approved for marketing by the FDA in August 2010 under the trade name Ella. For the prevention of pregnancy within 120h after unprotected sex or known or suspected contraceptive failure. Ulipristal acetate is a selective progesterone receptor modulator that exerts its emergency contraceptive effect primarily by inhibiting ovulation. The study found that ulipristal acetate was more effective than levonorgestrel in suppressing efflux when given close to the PSUR day (the highest chance of conception), this suggests that ulipristal acetate may have a stronger efficacy for emergency contraception. Figure 1 shows the structural formula of ulipristal acetate. |
biological activity | Ulipristal (CDB 3236) is a selective modulator of the progesterone receptor. Ulipristal binds to the progesterone receptor, thereby inhibiting PR-mediated gene expression and interfering with the activity of progesterone in the reproductive system. |