16188-55-9
4-(methylthio)phenylacetic acid
CAS: 16188-55-9
Molecular Formula: C9H10O2S
16188-55-9 - Names and Identifiers
16188-55-9 - Physico-chemical Properties
| Molecular Formula | C9H10O2S |
| Molar Mass | 182.24 |
| Density | 1.23±0.1 g/cm3(Predicted) |
| Melting Point | 97-98°C(lit.) |
| Boling Point | 337.4±25.0 °C(Predicted) |
| Flash Point | 121.1°C |
| Vapor Presure | 0.00475mmHg at 25°C |
| Appearance | powder to crystal |
| Color | White to Yellow to Orange |
| pKa | 4.34±0.10(Predicted) |
| Storage Condition | 2-8°C |
| Refractive Index | 1.562 |
| MDL | MFCD00192325 |
16188-55-9 - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
| HS Code | 29309099 |
16188-55-9 - Reference Information
| Application | Methylthiophenylacetic acid is the key intermediate for the preparation of etoricoxib. The traditional method is to prepare 4-methylthio phenylacetic acid by hydrolysis after Willgerodt-kindler rearrangement with 4-methylthio acetophenone. In the preparation of this compound, the Willgerodt-kindler rearrangement reaction is to prepare a thioamide intermediate through sulfur-raising and morpholine as the reaction reagent, and 4-methylthiophenylacetic acid is obtained by hydrolysis. |
| synthesis method | this preparation method is to provide a new synthesis route for the large environmental pollution problem existing in the current industrial production of 4-methylthiophenylacetic acid. It is based on common industrial raw materials p-halogenated phenylacetic acid and derivatives as the starting materials, and under the catalysis of cuprous ions, 4-methylthio phenylacetic acid and derivatives are generated, and 4-methylthio phenylacetic acid is obtained after post-treatment. The preparation of 4-methylthio phenylacetic acid, which comprises the following steps:(1) the compound 4-halo phenylacetic acid and its derivatives are reacted with sodium methylmercaptan, after acidification, to prepare 4-methylthio phenylacetic acid. The R1 group can be a carboxyl group, ester group, cyano group, amide and other groups that may form carboxyl groups. The R2 group is a halogen, preferably a bromine atom. (2) A catalyst must be used in the present invention, and one of the catalysts is cuprous ions, preferably cuprous bromide and cuprous chloride. (3) Another catalyst for this reaction is DMF, and DMF can also be a solvent. |
Last Update：2024-04-09 02:00:07
Supplier List
Featured Products
Product Name: 4-(methylthio)phenylacetic acid Request for quotationCAS: 16188-55-9
Tel: +86 18942506900
Email: 492657010@qq.com
Mobile: +86 18942506900
QQ: 492657010
Wechat: +86 18942506900
WhatsApp: +86 18942506900
Linkedin: +86 18942506900
Product Name: 4-Methylthiophenylacetic acid Request for quotation
CAS: 16188-55-9
Tel: +86 19849939632
Email: 2470479589@qq.com
Mobile: +86 19849939632
QQ: 2470479589
CAS: 16188-55-9
Tel: +86 19849939632
Email: 2470479589@qq.com
Mobile: +86 19849939632
QQ: 2470479589
Spot supply
Product Name: 4-(Methylthio)phenylacetic acid Visit Supplier Webpage Request for quotationCAS: 16188-55-9
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: 4-(Methylthio)phenylacetic acid Visit Supplier Webpage Request for quotationCAS: 16188-55-9
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Spot supply
Product Name: 4-(Methylthio)Phenylacetic Acid Visit Supplier Webpage Request for quotationCAS: 16188-55-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Featured Products
Product Name: 4-(methylthio)phenylacetic acid Request for quotationCAS: 16188-55-9
Tel: +86 18942506900
Email: 492657010@qq.com
Mobile: +86 18942506900
QQ: 492657010
Wechat: +86 18942506900
WhatsApp: +86 18942506900
Linkedin: +86 18942506900
Product Name: 4-Methylthiophenylacetic acid Request for quotation
CAS: 16188-55-9
Tel: +86 19849939632
Email: 2470479589@qq.com
Mobile: +86 19849939632
QQ: 2470479589
CAS: 16188-55-9
Tel: +86 19849939632
Email: 2470479589@qq.com
Mobile: +86 19849939632
QQ: 2470479589
Spot supply
Product Name: 4-(Methylthio)phenylacetic acid Visit Supplier Webpage Request for quotationCAS: 16188-55-9
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: 4-(Methylthio)phenylacetic acid Visit Supplier Webpage Request for quotationCAS: 16188-55-9
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Spot supply
Product Name: 4-(Methylthio)Phenylacetic Acid Visit Supplier Webpage Request for quotationCAS: 16188-55-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
View History
16188-55-9
Bronco
Polyvinylpyrrolidone
105140-25-8
2687-96-9
25736-86-1
500-66-3
3853-88-1
87776-75-8
422-77-5
Bronco
Polyvinylpyrrolidone
105140-25-8
2687-96-9
25736-86-1
500-66-3
3853-88-1
87776-75-8
422-77-5