1620278-72-9
1-(4-(Aminomethyl)benzyl)-2-butyl-1H-imidazo[4,5-c]quinolin-4-amine dihydrochloride
CAS: 1620278-72-9
Molecular Formula: C22H26ClN5
1620278-72-9 - Names and Identifiers
1620278-72-9 - Physico-chemical Properties
| Molecular Formula | C22H26ClN5 |
| Molar Mass | 395.94 |
| Solubility | Soluble in DMSO |
| Storage Condition | -20°C |
| Use | TLR7/8 agonist-5d is a TLR7/8 agonist which shows prominent immunostimulatory activities. |
| In vitro study | TLR7/8 agonist 1 (Compound 5d) shows prominent immunostimulatory activities. TLR7/8 agonist 1 serves as a convenient precursor for the covalent attachment of fluorophores without significant loss of activity. TLR7/8 agonist 1 retains TLR7-agonistic activity with an EC 50 of 20 nM. TLR7/8 agonist 1 (Compound 1) shows substantially different agonistic potencies in human TLR7 (50 nM) and TLR8 (55 nM) primary screens. |
1620278-72-9 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.313 ml | 11.564 ml | 23.127 ml |
| 5 mM | 0.463 ml | 2.313 ml | 4.625 ml |
| 10 mM | 0.231 ml | 1.156 ml | 2.313 ml |
| 5 mM | 0.046 ml | 0.231 ml | 0.463 ml |
Last Update：2024-01-02 23:10:35
1620278-72-9 - Reference Information
| biological activity | TLR7/8 agonist 1 dihydrochloride is a double agonist of toll-like receptor TLR7/TLR8. |
| target | TLR7/TLR8 |
| in vitro study | TLR7/8 agonist 1 (Compound 5d) shows prominent immunostimulatory activities. TLR7/8 agonist 1 serves as a convenient precursor for the covalent attachment of fluorophores without significant loss of activity. TLR7/8 agonist 1 retains TLR7-agonistic activity with an EC 50 of 20 nM. TLR7/8 agonist 1 (Compound 1) shows substantially different agonistic potencies in human TLR7 (50 nM) and TLR8 (55 nM) primary screens. |
Last Update：2024-04-09 15:16:37
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Spot supply
Product Name: 1-(4-(Aminomethyl)benzyl)-2-butyl-1H-imidazo[4,5-c]quinolin-4-amine dihydrochloride Visit Supplier Webpage Request for quotationCAS: 1620278-72-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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