164204-38-0

Name	Phosphoramidon (Disodium)
Synonyms	Phosphoramidon (Disodium) CRDWMOVRQCMROH-HIKRQZGHSA-N N-[N-[[(6-Deoxy-α-L-mannopyranosyl)oxy]hydroxyphosphinyl]-L-leucyl]-L-tryptophan disodium salt
CAS	164204-38-0

Molecular Formula	C23H34N3Na2O10P
Molar Mass	589.483
Solubility	H₂O: ≥ 140 mg/mL
Storage Condition	-20℃
In vitro study	Phosphoramidon is a potent inhibitor of thermolysin without inhibiting other endopeptidases such as trypsin, papain, and chymotrypsin. Phosphoramidon reduces tumor cell invasion in CC531 cells.
In vivo study	In rats bearing colon cancer CC531 xenografts, Phosphoramidon (250 mg/rat, I. P.) significantly reduced tumor cell growth. Intranasal phosphodipeptide increases β-amyloid levels in wild-type and NEP/nep2-deficient mice, allowing it to be used to mimic Alzheimer's disease (AD).

Last Update：2024-01-02 23:10:35

biological activity	phospho-aminidon diisodium Salt is a metabolite inhibitor that is widely used as a biochemical tool. Phosphoramidon inhibited ECE, NEP and ACE activities with IC50 values of 3.5 μm, 0.034 μm and 78 μm, respectively.
Target	Value

Last Update：2024-04-10 22:29:15

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164204-38-0

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