16423-68-0
Erythrosin B
CAS: 16423-68-0
Molecular Formula: C20H6I4Na2O5
16423-68-0 - Names and Identifiers
| Name | Erythrosin B |
| Synonyms | Eosin J Pyrosin B Iodeosin B C.I. 45430 Erythrosine ERYTHROSINE Acid Red 51 ERYTHROSIN B Erythrosin B Erythrosine B Food Red No.3 ERYTHROSINE B C.I. Acid Red 51 C.I. Food Red 14 ERYTHROSIN BLUISH ERYTHROSINE B STAIN Erythrosine B disodium ERYTHROSIN EXTRA BLUISH Erythrosin extra bluish ERYTHROSIN, DISODIUM SALT ERYTHROSIN B, POLYMER BOUND Tetraiodifluorescein, disodium salt Erythrosine sodium (close form) [USAN] Erythrosin B, high purity biological stain 2',4',5',7'-Tetraiodofluorescein, disodium salt disodium 2-(2,4,5,7-tetraiodo-6-oxido-3-oxo-3H-xanthen-9-yl)benzoate disodium 2',4',5',7'-tetraiodo-3-oxo-3H-spiro[2-benzofuran-1,9'-xanthene]-3',6'-diolate 2,4,5,7-Tetraiodo-3,6-dihydroxyxanthene-9-spiro-1'-3H-isobenzofuran-3'-one disodium salt 2',4',5',7'-Tetraiodo-3',6'-dihydroxy-spiro[3H-isobenzofuran-1,9'-xanthen]-3-one disodium salt Spiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one, 3',6'-dihydroxy-2',4',5',7'-tetraiodo-, disodium salt |
| CAS | 16423-68-0 |
| EINECS | 240-474-8 |
| InChI | InChI=1/C20H8I4O5.2Na/c21-11-5-9-17(13(23)15(11)25)28-18-10(6-12(22)16(26)14(18)24)20(9)8-4-2-1-3-7(8)19(27)29-20;;/h1-6,25-26H;;/q;2*+1/p-2 |
| InChIKey | RAGZEDHHTPQLAI-UHFFFAOYSA-L |
16423-68-0 - Physico-chemical Properties
| Molecular Formula | C20H6I4Na2O5 |
| Molar Mass | 879.86 |
| Density | 0.98 |
| Melting Point | 142~144℃ |
| Boling Point | 628.3°C at 760 mmHg |
| Flash Point | 285℃ |
| Water Solubility | Soluble in water |
| Solubility | 100g/l |
| Vapor Presure | 0Pa at 25℃ |
| Appearance | Fine Powder |
| Color | Deep red to brown |
| Maximum wavelength(λmax) | ['525nm'] |
| Merck | 14,3693 |
| BRN | 1443945 |
| pKa | 4.1(at 25℃) |
| PH | 6-7 (10g/l, H2O, 20℃) |
| Storage Condition | room temp |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| Physical and Chemical Properties | Hard and brittle white high melting point wax. At or above the melting point, soluble in mixed xylene, terpenes, butanol, methyl cellosolve and other high boiling point solvents and hot chlorinated hydrocarbons and aromatic solvents, but insoluble in water, ethanol, benzene, carbon tetrachloride, glycerol and other solvents. |
| Use | Coloring for food, pharmaceuticals and cosmetics |
16423-68-0 - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | 22 - Harmful if swallowed |
| Safety Description | 36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
| RTECS | LM5950000 |
| HS Code | 32129000 |
| Toxicity | LD50 in male, female mice, male, female rats (g/kg): 0.40, 0.32, 0.34, 0.37 i.p.; 6.7, 6.9, 7.4, 6.8 orally (Butterworth); LD50 in mice, rats (mg/kg): 2558, 2891 orally (Yankell) |
16423-68-0 - Reference Information
| color index | 45430 |
| pH indicator color change ph range | 0(yellow)-3.6(red) |
| main applications | color filter, light emitting diodes, nanosensors, imaging materials, inks, paints, colored bubbles, detergents, cleaners, cosmetics, oral care agent, hair dyes, antiseptic, treatment of burns, diabetes, obesity, cancer, viral diseases, radio chemotheray, photodynamic therapy |
| biological applications | Detecting gene expression,phosphoproteins,protease,stress biomarkers; treating age-related macular degeneration,arteriosclerosis,bone metabolic diseases,burns,cancer,diabetes,human immunodeficiency virus infection,obesity |
| LogP | -1.163 at 25℃ |
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| introduction | erythrosine B, also known as tetraiodofluorescein B, is a red or reddish brown particle or powder, odorless, soluble in water, soluble in ethanol, propylene glycol and glycerin, insoluble in oil. It has good staining, especially for protein staining. |
| application | compared with other synthetic red pigments of the same type, its heat resistance, alkali resistance, oxidation-reduction resistance and tinting strength are better, so it can be widely used in non-acidic foods such as fermented foods, baked foods, ice cream, fish cakes, pickled products, etc. |
| Preparation method | Dissolve fluorescein with sodium hydroxide solution to prepare fluorescein disodium salt, and then add 4 equivalents of iodine to it for iodine Subgeneration reaction to obtain erythrosine B. The operation of this synthetic route is relatively simple, and the current industrial preparation of tetraiodofluorescein B basically adopts this route. |
| content analysis | accurately weigh about 1.00g of the sample, dissolve it in 250ml of water, move it into a clean 500ml beaker, add 1.5mol/L nitric acid 8.0ml, and stir well. Filtered by a weighed sintered glass crucible (porosity 3, diameter 5cm) with a small glass rod. Wash with 0.5% nitric acid until the filtrate is not turbid when tested with silver nitrate test solution (TS-210), and then wash with 30ml of water. Dry at (135±5)℃ to constant weight, and carefully mash the residue with a glass rod. Weigh after cooling in the dryer. |
| toxicity | ADl 0~0.1mg // kg(FAO/WHO,2001). LD506800mg/kg (mice, oral);LD501840 mg/kg (rats, oral). |
| usage limit | GB 2760-2001(g/kg): seasoning sauce 0.05; Puffed food, fried food, birthday peach bag, 0.025; Juice (flavor) drinks, carbonated drinks, mixed wine, candy, pastries, green plum, candy coating, 0.05; Red and green silk, canned dyed cherries (for decoration),0.10; Candy coating 0.05. |
| use | mainly used as plastic lubricant, suitable for thermoplastic and thermosetting plastics such as polyethylene, polypropylene, polystyrene, ABS resin, polyvinyl chloride, etc. used for coloring food, medicine and cosmetics edible red pigment. Can be used for starch, baked goods, shrimp, ham, sausage, cherry, etc. Often used with other pigments. The dosage is 5~100mg/kg. as a food colorant, China stipulates that it can be used in red and green silk and canned dyed cherries (for decoration), with a maximum usage of 0.10 g/kg; In seasoning sauce, various beverages, prepared wine, candy, pastry coloring and green plum, the maximum usage is 0.05 g/kg. Eat red pigment. It is widely used in non-acidic foods such as fermented foods, baked foods, ice cream, fish cakes, pickled products, etc., and can also be used in conjunction with other food coloring. Not for drinks and hard candy. The usage amount is 5~100mg/kg. adsorption indicator for precipitation titration. Acid-base titration fluorescence indicator, pH greater than 2.5, no fluorescence, pH not less than 4.0, light green fluorescence. Photometric reagents. Biological stain. |
| production method | crude fluorescein obtained by heating and melting resorcinol, phthalic anhydride and anhydrous zinc chloride is refined and iodized, salted out with sodium chloride, and then refined. Preparation of erythrosine Resorcinol is heated and melted, added with phthalic anhydride, stirred and melted, heated to 185 ℃ for half an hour to form dark yellow resorcinolphthalide, which is in a liquid state. Add powdered anhydrous zinc chloride under stirring, stir until it is completely dissolved, and gradually raise the temperature to 210~215 ℃, heat until the reactants are completely solidified, then cool and pulverize to obtain a crude melt; the crude melt is heated with dilute hydrochloric acid In azeotrope, zinc chloride and residual resorcinol are leached, filtered, washed, and dried, and then ethanol is used to extract unreacted phenorcinolphthalide, and the extracted product is dried to obtain fluorescein. Dissolve fluorescein in sodium hydroxide solution, add iodine to react, add hydrochloric acid to the reactants, precipitate crystals, and then convert it into sodium salt solution, and concentrate to obtain the product. Preparation of erythrosine red aluminum lake Aluminum hydroxide is prepared from aluminum salts such as aluminum chloride, aluminum sulfate, etc. and bases such as sodium carbonate, and then added to erythrosine aqueous solution to precipitate the product. The product formed by the condensation of benzaldehyde -4-sulfonic acid and diethylm-aminophenol is dehydrated by concentrated sulfuric acid and oxidized with potassium dichromate, permanganate or ferric chloride to make sodium salt. |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-09 20:52:54
Supplier List
Product Name: Fluorescein Impurity 31 Request for quotation
CAS: 16423-68-0
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
CAS: 16423-68-0
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Product Name: Erythrosin B Request for quotation
CAS: 16423-68-0
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
CAS: 16423-68-0
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
Multiple SpecificationsSpot supply
Product Name: Pyrosine B Visit Supplier Webpage Request for quotationCAS: 16423-68-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Product Name: Fluorescein Impurity 31 Request for quotation
CAS: 16423-68-0
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
CAS: 16423-68-0
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Product Name: Erythrosin B Request for quotation
CAS: 16423-68-0
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
CAS: 16423-68-0
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
Multiple SpecificationsSpot supply
Product Name: Pyrosine B Visit Supplier Webpage Request for quotationCAS: 16423-68-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
View History