16616-39-0
MLS000532223
CAS: 16616-39-0
Molecular Formula: C15H9NO3
16616-39-0 - Names and Identifiers
| Name | MLS000532223 |
| Synonyms | MLS-532223 MLS000532223 1-(3-Nitrophenyl)-3-phenylprop-2-yn-1-one 1-(3-nitrophenyl)-3-phenyl-2-propyn-1-one 2-Propyn-1-one, 1-(3-nitrophenyl)-3-phenyl- |
| CAS | 16616-39-0 |
16616-39-0 - Physico-chemical Properties
| Molecular Formula | C15H9NO3 |
| Molar Mass | 251.24 |
| Density | 1.31±0.1 g/cm3(Predicted) |
| Melting Point | 120-121 °C |
| Boling Point | 419.6±47.0 °C(Predicted) |
| Solubility | Soluble in DMSO (up to 20 mg/ml). |
| Appearance | Solid |
| Color | Beige |
| Storage Condition | RT (des.) |
| Stability | Stable for 2 years as supplied. Solutions in DMSO may be stored at -20° for up to 2 months. |
| In vitro study | MLS000532223 prevents GTP binding to several GTPases in a dose-dependent manner. MLS000532223 modulates Rho-family GTP-binding kinetics. MLS000532223 is active in cell-based assays and inhibits EGF-stimulated Rac 1 activation. MLS000532223 inhibits actin rearrangements and changes in cell morphology that are downstream of Rho family GTPase activation. MLS000532223 (10 μM) modulates actin remodeling in mast cells. MLS000532223 (10 μM) inhibits ligand-stimulated β-hexosaminidase secretion of RBL cells. |
16616-39-0 - Reference Information
| biological activity | MLS000532223 is a high affinity selective inhibitor of Rho family GTPases, with EC50 values ranging from 16 μM to 120 μM. |
| target | TargetValue Rho (Cell-free say) 16 μM(EC50) |
| Target | Value |
| Rho (Cell-free assay) | 16 μM(EC50) |
| in vitro study | MLS000532223 prevents GTP binding to several GTPases in a pose-dependent manner. MLS000532223 modulates Rho-family GTP-binding kinetics. MLS000532223 is active in cell-based assets and inhibits EGF-stimulated Rac 1 activation. MLS000532223 inhibits actin rearrangements and changes in cell morphology that are downstream of Rho family GTPase activation. MLS000532223 (10 μ M) modulates actin remodeling in mast cells. MLS000532223 (10 μM) inhibits ligand-stimulated β-hexosaminidase secretion of RBL cells. |
Last Update：2024-04-10 22:29:15
