166734-06-1

Name	cis-Mulberroside A
Synonyms	cis-Mulberroside A beta-D-Glucopyranoside 3-[(1Z)-2-[4-(beta-D-glucopyranosyloxy)-2-hydroxyphenyl]ethenyl]-5-hydroxyphenyl
CAS	166734-06-1

biological activity	cis-Mulberroside A (Mulberroside D) is the cis-isomer of Mulberroside A. Mulberroside A is one of the main bioactive components in Morus alba L. Mulberroside A reduced the expression of TNF-α,IL-1β and IL-6, inhibited the activation of NALP3,caspase-1 and NF-κB and the phosphorylation of ERK,JNK and p38. Mulberroside A has anti-inflammatory and anti-apoptotic effects. Mulberroside A has inhibitory activity against mushroom tyrosinase with an IC50 of 53.6 μm.
Animal Model:	Male Kun-Ming mice (20±2 g)
Dosage:	5, 10, 20, and 40 mg/kg; the dose volume 10 mL/kg body weight
Administration:	Orally initiated at 9:00 a.m.
Result:	10, 20, and 40 mg/kg significantly increased urinary urate excretion in 24 h, resulting in a remarkable elevation of fractional excretion of uric acid (FEUA), and the highest dose completely reversed FEUA alteration of hyperuricemic mice to normal.

Last Update：2024-04-09 21:54:55

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166734-06-1

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