1670-46-8
2-Acetylcyclopentanone
CAS: 1670-46-8
Molecular Formula: C7H10O2
1670-46-8 - Names and Identifiers
1670-46-8 - Physico-chemical Properties
| Molecular Formula | C7H10O2 |
| Molar Mass | 126.15 |
| Density | 1.043 g/mL at 25 °C (lit.) |
| Melting Point | 60-70℃ |
| Boling Point | 72-75 °C/8 mmHg (lit.) |
| Flash Point | 163°F |
| Vapor Presure | 0.00713mmHg at 25°C |
| Appearance | clear liquid |
| Specific Gravity | 1.043 |
| Color | Colorless to Light yellow to Light orange |
| BRN | 1857601 |
| pKa | 10.87±0.20(Predicted) |
| Storage Condition | Store at +2°C to +8°C. |
| Refractive Index | n20/D 1.489(lit.) |
| MDL | MFCD00001413 |
1670-46-8 - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | 22 - Harmful if swallowed |
| Safety Description | 36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
| RTECS | GY4728000 |
| FLUKA BRAND F CODES | 8-10-23 |
| HS Code | 29142900 |
1670-46-8 - Reference Information
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| application | 2-acetylcyclopentanone is a pharmaceutical intermediate and organic synthesis intermediate, which can be used in laboratory research and development process and chemical pharmaceutical synthesis process. 2-Acetylcyclopentanone is a pharmaceutical intermediate, which can be prepared from 1-(trimethylsiloxy) cyclopentene in one step. It has been reported that 2-acetylcyclopentanone can be used to prepare antiepileptic drugs and EZH2 inhibitors. |
| Preparation | General step: obtain a potassium solution by contacting the potassium mirror with a THF(02 mol / L) solution of 18-crown-6 at -20°C. Drop an appropriate amount of ketone (THF solution, 1mol / L) to the resulting blue potassium solution ([K-] = 022mol / L) until discoloration. The obtained naphthylenate and alkyd esters were subsequently alkylated or acylated. For this purpose, methyl iodide or acetyl chloride is added to the enolate under argon. The reaction was carried out at room temperature for 60 minutes. The potassium halide formed is separated by filtration. The reaction products were then separated and analyzed using conventional preparation methods. The purity of all compounds obtained was> amp; gt; 96%(GC) and appropriate spectral and analytical data were provided. 2-Acetylcyclopentanone, yield 32%. |
Last Update：2024-04-09 18:58:34
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