167933-07-5
Flibanserin
CAS: 167933-07-5
Molecular Formula: C20H21F3N4O
167933-07-5 - Names and Identifiers
| Name | Flibanserin |
| Synonyms | Bimt 17 BIMT-17 Fbanselin BIMT-17BS Flubanserin Flibanserin Flibaneserin Niemunerkeine Flibaserin(female) Flubensin (female) 3-[2-[4-[3-(trifluoromethyl)phenyl]-1-piperazinyl]ethyl]-1H-benzimidazol-2-one 3-[2-[4-[4-(Trifluoromethyl)phenyl]piperazin-1-yl]ethyl]-1H-benzimidazol-2-one 1-(2-{4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}ethyl)-1,3-dihydro-2H-benzimidazol-2-one 1-(2-{4-[4-(trifluoromethyl)phenyl]piperazin-1-yl}ethyl)-1,3-dihydro-2H-benzimidazol-2-one |
| CAS | 167933-07-5 |
| EINECS | 643-002-2 |
| InChI | InChI=1/C20H21F3N4O/c21-20(22,23)15-4-3-5-16(14-15)26-11-8-25(9-12-26)10-13-27-18-7-2-1-6-17(18)24-19(27)28/h1-7,14H,8-13H2,(H,24,28) |
| InChIKey | PPRRDFIXUUSXRA-UHFFFAOYSA-N |
167933-07-5 - Physico-chemical Properties
| Molecular Formula | C20H21F3N4O |
| Molar Mass | 390.4 |
| Density | 1.292±0.06 g/cm3(Predicted) |
| Solubility | DMSO: soluble10mg/mL, clear |
| Appearance | powder |
| Color | white to beige |
| pKa | 12.12±0.30(Predicted) |
| Storage Condition | 2-8°C |
| Refractive Index | 1.566 |
| In vivo study | The multifunctional serotonergic agent Flibanserin is both a serotonin 1A agonist and a serotonin 2A antagonist. Flibanserin theoretically improves sexual functioning by enhancing downstream release of dopamine and norepinephrine while reducing serotonin release in the brain circuits that mediate symptoms of reduced sexual interest and desire. Flibanserin, a new molecular entity for the treatment of hypoactive sexual desire disorder (HSDD) in premenopausal women. Flibanserin improves interest in and desire for sex by hypothetically targeting these circuits and causing the release of dopamine and norepinephrine while also reducing the release of serotonin. Flibanserin has demonstrated clinical efficacy in premenopausal women who have reduced interest in and desire for sex and has 2 principal pharmacologic actions in microcircuits: it is a full agonist at postsynaptic serotonin 5HT1A receptors and an antagonist at postsynaptic 5HT2A receptors. |
167933-07-5 - Risk and Safety
| Hazard Symbols | T - Toxic |
| Risk Codes | R25 - Toxic if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| UN IDs | UN 2811 6.1 / PGIII |
| WGK Germany | 3 |
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