169287-69-8
G(Cbz)-acetic acid
CAS: 169287-69-8
Molecular Formula: C15H13N5O5
169287-69-8 - Names and Identifiers
169287-69-8 - Physico-chemical Properties
| Molecular Formula | C15H13N5O5 |
| Molar Mass | 343.29 |
| Density | 1.60±0.1 g/cm3(Predicted) |
| pKa | 3.71±0.10(Predicted) |
169287-69-8 - Introduction
G-Cbz-acetic acid (1,6-dihydro -6-oxo-2- [[(phenylmethoxy) carbonyl] amino]-9H-purine-9-acetic acid), also known as G(Cbz)-acetic acid, is a compound. The following is a description of its nature, use, formulation and safety information:
Nature:
1. Appearance: White crystalline solid.
2. molecular formula: C22H23N5O6.
3. Molecular weight: 469.45g/mol.
Use:
1. G(Cbz)-acetic acid can be used as a protecting group in organic synthesis and is often used to protect amino groups.
2. It can also be used as a synthetic intermediate in nucleic acid pharmaceutical chemistry.
Preparation Method:
The preparation of G(Cbz)-acetic acid can be carried out by the following steps:
1. Benzaldehyde reacts with ethylenediamine to generate the corresponding 1,6-diaza -2-amino-purine product.
2. The product reacts with diethyl dicarbonate to form 1,6-diaza -2-[[diethoxycarbonyl] amino]-9H-purine -9-acetic acid ethylenediamine ester.
3. Finally, the target product G(Cbz)-acetic acid was obtained by an acidic hydrogenation reaction.
Safety Information:
1. G(Cbz)-acetic acid dust may be irritating to eyes, skin and respiratory tract, and protective glasses and gloves should be worn for operation.
2. During operation, avoid contact with skin and inhalation of dust.
3. It should be stored in a dry, cool place, and avoid contact with oxidants and strong acids.
4. When handling the compound, follow appropriate laboratory practices and safe operating procedures.
Please note that G(Cbz)-acetic acid is a professional chemical reagent and should only be used in a suitable laboratory environment. Before use, you should first understand its safe operation and storage requirements in detail, and operate in accordance with relevant regulations.
Nature:
1. Appearance: White crystalline solid.
2. molecular formula: C22H23N5O6.
3. Molecular weight: 469.45g/mol.
Use:
1. G(Cbz)-acetic acid can be used as a protecting group in organic synthesis and is often used to protect amino groups.
2. It can also be used as a synthetic intermediate in nucleic acid pharmaceutical chemistry.
Preparation Method:
The preparation of G(Cbz)-acetic acid can be carried out by the following steps:
1. Benzaldehyde reacts with ethylenediamine to generate the corresponding 1,6-diaza -2-amino-purine product.
2. The product reacts with diethyl dicarbonate to form 1,6-diaza -2-[[diethoxycarbonyl] amino]-9H-purine -9-acetic acid ethylenediamine ester.
3. Finally, the target product G(Cbz)-acetic acid was obtained by an acidic hydrogenation reaction.
Safety Information:
1. G(Cbz)-acetic acid dust may be irritating to eyes, skin and respiratory tract, and protective glasses and gloves should be worn for operation.
2. During operation, avoid contact with skin and inhalation of dust.
3. It should be stored in a dry, cool place, and avoid contact with oxidants and strong acids.
4. When handling the compound, follow appropriate laboratory practices and safe operating procedures.
Please note that G(Cbz)-acetic acid is a professional chemical reagent and should only be used in a suitable laboratory environment. Before use, you should first understand its safe operation and storage requirements in detail, and operate in accordance with relevant regulations.
Last Update：2024-04-09 21:00:56
