17,21-Dihydroxyprogesterone

17,21-Dihydroxyprogesterone - Names and Identifiers

Name	Cortexolone
Synonyms	Cortifen SKF 3050 Compound S Cortodoxone Cortexolone Reichstein S 11-Dioxycortisol 11-Deoxycortisol cortodoxone (INN) 11-Desoxycortisol 11-Deoxycortisone 11-Desoxycortisone Cortisol, 11-dioxy- Cortisol, 11-deoxy- 17α-Hydroxycortexone 17a-Hydroxycortexone 11-Deoxyhydrocortisone 11-Desoxyhydrocortisone Reichstein's Substanz S Reichstein's compound S Reichstein's substance S 17,21-Dihydroxyprogesterone 17α,21-Dihydroxyprogesterone 17a,21-Dihydroxyprogesterone 4-Pregnen-17a,21-diol-3,20-dion 4-Pregnen-17α,21-diol-3,20-dion 11-Deoxy-17-hydrocorticosterone 17-Hydroxy-11-deoxycorticosterone 11-Deoxy-17-hydroxycorticosterone 4-Pregnene-17α, 21-diol-3,20-dione 11-Desoxy-17-hydroxycorticosterone 4-Pregnene-17a, 21-diol-3,20-dione 11-Desoxy-17a-hydroxycorticosterone 11-Desoxy-17α-hydroxycorticosterone Corticosterone, 11-deoxy-17-hydroxy- 17a,21-Dihydroxy-4-pregnen-3,20-dion 17α,21-Dihydroxy-4-pregnen-3,20-dion 17,21-Dihydroxypregn-4-ene-3,20-dione 17,21-Dihydroxy-4-pregnene-3,20-dione 17,21-dihydroxy-pregn-4-ene-3,20-dione 17a,21-dihydroxypregn-4-ene-3,20-dione 17α,21-dihydroxypregn-4-ene-3,20-dione Pregn-4-ene-3,20-dione, 17,21-dihydroxy- PCB NO.101-2,2',4,5,5'-PENTACHLOROBIPHENYL 17alpha,21-Dihydroxypregn-4-ene-3,20-dione (8xi,9xi,10xi,13xi,14xi)-17,21-dihydroxypregn-4-ene-3,20-dione (8R,10R,13S,17R)-17-Hydroxy-17-(2-hydroxy-acetyl)-10,13-dimethyl-1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-cyclopenta[a]phenanthren-3-one
CAS	152-58-9 37-60-5
EINECS	205-805-2
InChI	InChI=1/C21H30O4/c1-19-8-5-14(23)11-13(19)3-4-15-16(19)6-9-20(2)17(15)7-10-21(20,25)18(24)12-22/h11,15-17,22,25H,3-10,12H2,1-2H3/t15-,16+,17+,19+,20+,21+/m1/s1

17,21-Dihydroxyprogesterone - Physico-chemical Properties

Molecular Formula	C21H30O4
Molar Mass	346.4605
Density	1.22g/cm³
Melting Point	205-208℃
Boling Point	524.5°C at 760 mmHg
Flash Point	285.1°C
Solubility	Soluble in acetone, methanol and ethanol, slightly soluble in water and ether
Vapor Presure	3.41E-13mmHg at 25°C
Appearance	Crystalline solid
Storage Condition	2-8℃
Sensitive	Sensitive to air
Refractive Index	1.577
MDL	MFCD00003662

17,21-Dihydroxyprogesterone - Risk and Safety

Safety Description

S24/25 - Avoid contact with skin and eyes.

17,21-Dihydroxyprogesterone - Reference

Reference

1. Chen, Jing, et al. "Identification of Absidia orchidis steroid 11β-hydroxylation system and its application in engineering Saccharomyces cerevisiae for one-step biotransformation to produce hydrocortisone." Metabolic engineering 57 (2020): 31-42.https://do
2. [IF=9.783] Jing Chen et al."Identification of Absidia orchidis steroid 11β-hydroxylation system and its application in engineering Saccharomyces cerevisiae for one-step biotransformation to produce hydrocortisone."Metab Eng. 2020 Jan;57:31