17-alpha,21-dihydroxypregna-4,9(11)-diene-3,20-dione21-acetate
Anecortave Acetate
CAS: 7753-60-8
Molecular Formula: C23H30O5
17-alpha,21-dihydroxypregna-4,9(11)-diene-3,20-dione21-acetate - Names and Identifiers
17-alpha,21-dihydroxypregna-4,9(11)-diene-3,20-dione21-acetate - Physico-chemical Properties
| Molecular Formula | C23H30O5 |
| Molar Mass | 386.48 |
| Density | 1.23±0.1 g/cm3(Predicted) |
| Melting Point | 230-234°C |
| Boling Point | 551.8±50.0 °C(Predicted) |
| Specific Rotation(α) | D +117° (c = 1.0 in CHCl3); D22 +124° (c = 1.04 in CHCl3). |
| Solubility | Chloroform (Slightly), Methanol (Slightly) |
| Appearance | Solid |
| Color | Off-White to Beige |
| pKa | 12.47±0.60(Predicted) |
| Storage Condition | -20°C Freezer |
| Physical and Chemical Properties | Chemical properties crystallization (methanol). Melting point 216 ℃. |
| Use | Use: Intermediate of xiyanshusong A acetate, skin easy acetate, and hydrofluoro-cortisone acetate. |
17-alpha,21-dihydroxypregna-4,9(11)-diene-3,20-dione21-acetate - Nature
| specific rotation | D 117° (c = 1.0 in CHCl3); D22 124° (c = 1.04 in CHCl3). |
| storage conditions | -20°C Freezer |
| acidity coefficient (pKa) | 12.47±0.60(Predicted) |
Last Update：2024-04-10 22:29:15
17-alpha,21-dihydroxypregna-4,9(11)-diene-3,20-dione21-acetate - Production method
It can be acetylated with 11 α,17 α,21-trihydroxygestroster-4-ene-3, 20-dione (I. e. epihydrocortisone) by (21-hydroxy group), (11-hydroxy group) sulfonylation, and then elimination (removal of toluene sulfonic acid) to form 9(11)-double bond to prepare the product.
Last Update：2024-04-10 22:29:15
17-alpha,21-dihydroxypregna-4,9(11)-diene-3,20-dione21-acetate - Introduction
An ecortave Acetate is an organic compound. It is a colorless crystal, the common form is a white solid with aroma. The following is an introduction to the nature, use, formulation and safety information of Anecortave Acetate:
Nature:
-chemical formula: C8H9NO
-Molecular weight: 135.17g/mol
-Melting Point: 114-115 ℃
-Boiling point: 304 ℃
-Density: 1.22g/cm³
-Soluble in alcohol, ether and chloroform, slightly soluble in water
Use:
- Anecortave Acetate is widely used in the synthesis of drugs and dyes.
-It can be used as a raw material for antipyretic and analgesic drugs, such as paracetamol.
-In the dye industry, it can be used as a dye precursor for the synthesis of dyes.
-In addition, Anecortave Acetate can also be used for some experiments in medical and chemical laboratories.
Preparation Method:
The preparation of Anecortave Acetate is usually carried out by the esterification reaction of acetic acid and aniline. The specific steps include: aniline and acetic acid are reacted under the catalysis of sulfuric acid to produce Anecortave Acetate, and then purified by crystallization to obtain pure product.
Safety Information:
- Anecortave Acetate is toxic and may pose a health hazard.
-It may cause irritation to the skin, eyes and respiratory tract, so pay attention to avoid contact when using.
-Wear appropriate personal protective equipment such as goggles, gloves and protective masks during handling and handling.
-Keep away from fire and oxidizing agents and store in a cool, dry and well-ventilated place.
-When using, storing and handling Anecortave Acetate, Please strictly follow the safety procedures and relevant regulations.
Nature:
-chemical formula: C8H9NO
-Molecular weight: 135.17g/mol
-Melting Point: 114-115 ℃
-Boiling point: 304 ℃
-Density: 1.22g/cm³
-Soluble in alcohol, ether and chloroform, slightly soluble in water
Use:
- Anecortave Acetate is widely used in the synthesis of drugs and dyes.
-It can be used as a raw material for antipyretic and analgesic drugs, such as paracetamol.
-In the dye industry, it can be used as a dye precursor for the synthesis of dyes.
-In addition, Anecortave Acetate can also be used for some experiments in medical and chemical laboratories.
Preparation Method:
The preparation of Anecortave Acetate is usually carried out by the esterification reaction of acetic acid and aniline. The specific steps include: aniline and acetic acid are reacted under the catalysis of sulfuric acid to produce Anecortave Acetate, and then purified by crystallization to obtain pure product.
Safety Information:
- Anecortave Acetate is toxic and may pose a health hazard.
-It may cause irritation to the skin, eyes and respiratory tract, so pay attention to avoid contact when using.
-Wear appropriate personal protective equipment such as goggles, gloves and protective masks during handling and handling.
-Keep away from fire and oxidizing agents and store in a cool, dry and well-ventilated place.
-When using, storing and handling Anecortave Acetate, Please strictly follow the safety procedures and relevant regulations.
Last Update：2024-04-09 20:52:54
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Product Name: Hydrocortisone Impurity 17 Visit Supplier Webpage Request for quotationCAS: 7753-60-8
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Product Name: Anecortave Visit Supplier Webpage Request for quotation
CAS: 7753-60-8
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Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
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CAS: 7753-60-8
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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