Name | Quinestrol |
Synonyms | eston eecpe Quinestrol 17-alpha-ethinylestradiol3-cyclopentylether 17a-ethynyl-1,3,5(10)-estratriene-3,17b-diol 3-cyclopentyl ether (17beta)-3-(cyclopentyloxy)-17-ethynylestra-1,3,5(10)-trien-17-ol 3-cyclopentyloxy-17-alpha-ethynyloestra-1,3,5(10)-trien-17-beta-ol 3-(cyclopentyloxy)-(17-alpha)-19-norpregna-5(10)-trien-20-yn-17-ol 5(10)-trien-20-yn-17-ol,3-(cyclopentyloxy)-19-nor-17-alpha-pregna-3 3-(cyclopentyloxy)-19-nor-17-alpha-pregna-1,3,5(10)-trien-20-yn-17-ol 17ALPHA-ETHYLNYL-1,3,5[10]ESTRATRIENE-3,17BETA-DIOL 3-CYCLOPENTYL ETHER |
CAS | 152-43-2 |
EINECS | 205-803-1 |
InChI | InChI=1/C25H32O2/c1-3-25(26)15-13-23-22-10-8-17-16-19(27-18-6-4-5-7-18)9-11-20(17)21(22)12-14-24(23,25)2/h1,9,11,16,18,21-23,26H,4-8,10,12-15H2,2H3/t21-,22-,23+,24+,25+/m1/s1 |
Molecular Formula | C25H32O2 |
Molar Mass | 364.52 |
Density | 1.0693 (rough estimate) |
Melting Point | 107-108° |
Boling Point | 435.69°C (rough estimate) |
Specific Rotation(α) | D25 +5° (c = 0.5 in dioxane) |
Flash Point | 218.8°C |
Solubility | Chloroform (Slightly), Dioxane (Slightly), DMSO (Slightly), Methanol (Slightly) |
Vapor Presure | 6.43E-11mmHg at 25°C |
Appearance | Crystal |
Color | White to Off-White |
Merck | 14,8055 |
pKa | 13.10±0.40(Predicted) |
Storage Condition | 2-8°C |
Refractive Index | 1.4480 (estimate) |
Use | Used as an estrogen |
Hazard Symbols | T - Toxic |
Risk Codes | R45 - May cause cancer R61 - May cause harm to the unborn child R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R46 - May cause heritable genetic damage |
Safety Description | S53 - Avoid exposure - obtain special instructions before use. S22 - Do not breathe dust. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
WGK Germany | 3 |
RTECS | RC8948000 |
This product is 3-cyclopentyloxy-19-nor-17a-pregnan-1, 3,5 (10 )-Tris -20-alkyn-17-alcohol. Based on the dry product, the content of C25H3202 should be 97.5% ~ 102.5%.
The melting point of this product (General 0612) is 106~112°C.
take this product, precision weighing, plus dioxane dissolution and quantitative dilution of about 10 mg per lml solution, according to the law (General 0621), the specific rotation is 0 ° to 50 °.
take this product, add anhydrous ethanol to dissolve and dilute to make a solution containing about 4mg per lml as a test solution; Take lml for precision measurement and put it in a 100ml measuring flask, as a control solution, it was diluted to scale with absolute ethanol and shaken. According to the chromatographic conditions under the content determination item, 20 u1 of the test solution and the control solution are respectively injected into the liquid chromatograph, and the chromatogram is recorded to 2 times of the retention time of the main component peak. If there are impurity peaks in the chromatogram of the test solution, the sum of each impurity peak area shall not be more than 3 times (3.0%) of the main peak area of the control solution.
take this product, dry to constant weight at 80°C, weight loss shall not exceed 1.0% (General rule 0831).
measured by high performance liquid chromatography (General 0512).
silica gel bonded with eighteen alkyl silane was used as a filler; Methanol-water (90:10) was used as a mobile phase; The detection wavelength was 279mn. Take the appropriate amount of ethinyl estradiol and ethinyl estradiol respectively, add absolute ethanol to dissolve and dilute to make each containing 0.lmg mixed solution, take 20m1 injection liquid chromatograph, the number of theoretical plate is not less than 2000 according to the peak of ethinyl estradiol, and the separation degree between ethinyl estradiol peak and ethinyl estradiol peak should be greater than 12.
take an appropriate amount of this product, weigh it accurately, add anhydrous ethanol to dissolve and quantitatively dilute to make a solution containing about 0.4mg per lml, as a test solution, the chromatogram was recorded by injection of 20u1 into human liquid chromatograph, and an appropriate amount of reference substance of ethinyl estradiol was taken for determination by the same method. According to the external standard method to calculate the peak area, that is.
estrogen drugs.
sealed storage.