171338-27-5

171338-27-5 - Names and Identifiers

Name	2-(R)-[1-(R)-(3,5-Bis(trifluoromethyl)phenyl)ethoxy]-3-(S)-fluorophenylmorpholine
Synonyms	(2R, 3S)-2-(1R)-1-3,5-Bis(trifluoroMethyl) phenyl) (2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl]ethoxy]-3-(4-fluorophenyl)morpholine 2-(R)-[1-(R)-(3,5-Bis(trifluoromethyl)phenyl)ethoxy]-3-(S)-fluorophenylmorpholine (2R,3S)-2-((R)-1-(3,5-bis(trifluoroMethyl)phenyl)ethoxy)-3-(4-fluorophenyl)Morpholine (2R,3S)-2-{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy}-3-(4-fluorophenyl)morpholine (2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl)ethoxy]-3-(4-fluorophenyl)-morpholine Morpholine,2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-, (2R,3S)- Morpholine,2-[1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-, [2R-[2a(R*),3a]]- 2-(R)-[1-(R)-(3,5-Bis(trifluoromethyl)phenyl)ethoxy]-3-(S)-fluorophenylmorpholine[Aprepitant-M2]
CAS	171338-27-5
InChI	InChI=1/C20H18F7NO2/c1-11(13-8-14(19(22,23)24)10-15(9-13)20(25,26)27)30-18-17(28-6-7-29-18)12-2-4-16(21)5-3-12/h2-5,8-11,17-18,28H,6-7H2,1H3/t11-,17+,18-/m1/s1

171338-27-5 - Physico-chemical Properties

Molecular Formula	C20H18F7NO2
Molar Mass	437.35
Density	1.37±0.1 g/cm3(Predicted)
Boling Point	387.9±42.0 °C(Predicted)
Flash Point	188.369°C
Solubility	Chloroform (Slightly), Methanol (Slightly, Heated)
Vapor Presure	0mmHg at 25°C
Appearance	Solid
Color	Yellow Low Melting
pKa	6.93±0.60(Predicted)
Storage Condition	Sealed in dry,2-8°C
Refractive Index	1.505

171338-27-5 - Introduction

2-(R)-[1-(R)-(3,5-bis (trifluoromethyl)phenyl)ethoxy]-3-(S)-fluorophenylmorpholine is a compound, its nature, use, formulation and safety information are as follows:

Nature:
-Appearance: Colorless solid
-molecular formula: C23H20F5NO2
-Molecular weight: 461.41g/mol
-Melting Point: 135-140 ° C
-Thermal stability: Stable

Use:
- 2-(R)-[1-(R)-(3,5-bis (trifluoromethyl)phenyl)ethoxy]-3-(S)-fluorophenylmorpholine is a chiral skeleton compound, which is commonly used in asymmetric catalytic reactions in organic synthesis, especially asymmetric hydrogenation reactions and asymmetric carbon-carbon bond construction reactions.

Method:
- 2-(R)-[1-(R)-(3,5-bis (trifluoromethyl)phenyl)ethoxy]-3-(S) the preparation of-fluorophenylmorpholine is more complex and generally requires a multi-step synthesis process. A common method of preparation is by tandem reaction of synthetic intermediates, starting from available starting materials.

Safety Information:
- 2-(R)-[1-(R)-(3,5-bis (trifluoromethyl)phenyl)ethoxy]-3-(S)-Safety and toxicity information for fluorophenylmorpholine is currently unknown. Since the compound is a chiral skeleton compound, it is necessary to pay attention to the relevant chemical laboratory operation specifications when used. For further information on safety and toxicity, please refer to the literature or consult a professional chemist.

Last Update：2024-04-10 22:29:15