172217-02-6

172217-02-6 - Names and Identifiers

Name	7-(trifluoromethyl)-1H-indole
Synonyms	7-(Trifluoromethyl) 7-(trifluoromethyl)-1H-indole 1H-indole, 7-(trifluoromethyl)- 1H-Indole, 7-(trifluoromethyl)-
CAS	172217-02-6
InChI	InChI=1/C9H6F3N/c10-9(11,12)7-3-1-2-6-4-5-13-8(6)7/h1-5,13H

172217-02-6 - Physico-chemical Properties

Molecular Formula	C9H6F3N
Molar Mass	185.15
Density	1.367±0.06 g/cm3(Predicted)
Boling Point	256.7±35.0 °C(Predicted)
Flash Point	109.034°C
Vapor Presure	0.024mmHg at 25°C
pKa	15.16±0.30(Predicted)
Storage Condition	Sealed in dry,Room Temperature
Refractive Index	1.556

172217-02-6 - Introduction

7-(trifluoromethyl)-1H-indole is an organic compound with the chemical formula C9H5F3N. The following is a description of its nature, use, preparation and safety information:

Nature:
-Appearance: 7-(trifluoromethyl)-1H-indole is a white crystalline or powdery solid.
-Melting point: about 83-85 degrees Celsius.
-Boiling point: About 280 degrees Celsius.
-Solubility: It dissolves in some organic solvents (such as benzene, ethanol and methanol), but is almost insoluble in water.

Use:
-Chemical research: 7-(trifluoromethyl)-1H-indole is widely used as an intermediate for the synthesis of organic compounds and drugs. It is often used in synthetic chemistry to construct the skeleton of aromatic compounds.
-Drug development: It is used in the pharmaceutical field to prepare anti-cancer drugs, antiviral drugs and other biologically active molecules.

Method:
The preparation of 7-(trifluoromethyl)-1H-indole is generally carried out by the following steps:
1. Reaction of indole with Trifluoromethyl iodide: reaction of indole with Trifluoromethyl iodide gives trifluoromethyl indolyl intermediate.
2. Intermediate rearrangement: the intermediate is rearranged to form 7-(trifluoromethyl)-1H-indole.

Safety Information:
- 7-(trifluoromethyl)-1H-indole should be regarded as a harmful substance, which may cause irritation and damage to the human body.
-Wear appropriate safety gloves, goggles and protective clothing during operation.
-Avoid inhaling its dust or solution, and keep away from fire and high temperature.
-In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical help.

Please note that the use of any chemical reagent should follow the correct laboratory safety procedures, and according to the specific situation to assess the risk and take appropriate protective measures.

Last Update：2024-04-09 15:17:53