17228-75-0

17228-75-0 - Names and Identifiers

Name	2,6-DICHLORO-4-METHOXY-PYRIDINE
Synonyms	4-Methoxy-2,6-dichloropyridine 2,6-DICHLORO-4-METHOXY-PYRIDINE Pyridine, 2,6-dichloro-4-methoxy-
CAS	17228-75-0

17228-75-0 - Physico-chemical Properties

Molecular Formula	C6H5Cl2NO
Molar Mass	178.02
Density	1.363±0.06 g/cm3(Predicted)
Boling Point	255.0±35.0 °C(Predicted)
pKa	-0.91±0.10(Predicted)
Storage Condition	Inert atmosphere,Room Temperature

17228-75-0 - Reference Information

Introduction

2, 6-dichloro-4-methoxypyridine is an organic intermediate, it can be obtained from 2-chloro-4-methoxypyridine oxynitride by two-step preparation or from 2, 6-dichloro-4-nitropyridine by one-step preparation.

preparation method

2, 6-dichloro-4-nitropyridine (1.0equiv.) potassium carbonate (3equiv.) and methanol (20equiv.) the mixture was heated to 70 °c for 25min In a microwave. The reaction mixture was diluted with methanol and decanted from the remaining solid. After concentration, the mixture was partitioned between water and EtOAc. The organic phase was washed with brine and dried over sodium sulfate. The solution was concentrated and dried in vacuo to give 2, 6-dichloro-4-methoxypyridine in 88% yield. LCMS(m/z)(M H)= 177.9/179.9,Rt = 0.72min.

Last Update：2024-04-10 22:29:15