17257-71-5

17257-71-5 - Names and Identifiers

Name	(S)-(-)-A-methoxy-A-(trifluoromethyl)phenylacetic acid
Synonyms	(-)MTPA (-)-Moshers acid (S)-(-)-Mosheracid (-)-MTPA, Moshers acid (-)-Moshers acid~(-)-MTPA 3,3,3-trifluoro-2-methoxy-2-phenylpropanoic acid [S,(-)]-β,β,β-Trifluoro-α-methoxyhydratropic acid minus-A-methoxy-A-trifluoro-methyl*phenylacetic A (2S)-3,3,3-trifluoro-2-methoxy-2-phenylpropanoate (2R)-3,3,3-trifluoro-2-methoxy-2-phenylpropanoate (S)-2-Methoxy-2-phenyl-3,3,3-trifluoropropanoic acid [S,(-)]-α-Trifluoromethyl-α-methoxyphenylacetic acid (2S)-3,3,3-trifluoro-2-methoxy-2-phenylpropanoic acid (2R)-3,3,3-trifluoro-2-methoxy-2-phenylpropanoic acid (S)-(-)-A-methoxy-A-(trifluoromethyl)phenylacetic acid [S,(-)]-3,3,3-Trifluoro-2-methoxy-2-phenylpropionic acid (S)-(-)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetic acid (S)-(-)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetic Acid [Optical Resolving]
CAS	17257-71-5
EINECS	241-292-1
InChI	InChI=1/C10H9F3O3/c1-16-9(8(14)15,10(11,12)13)7-5-3-2-4-6-7/h2-6H,1H3,(H,14,15)/p-1/t9-/m1/s1

17257-71-5 - Physico-chemical Properties

Molecular Formula	C10H9F3O3
Molar Mass	234.17
Density	1.303g/mLat 25°C(lit.)
Melting Point	46-49°C(lit.)
Boling Point	95-97°C0.05mm Hg(lit.)
Specific Rotation(α)	D24 -71.8± 0.6° (c = 3.28 in CH3OH)
Flash Point	>230°F
Solubility	Readily soluble in hexane, ether, THF, CH2Cl2, benzene.
Vapor Presure	0.00117mmHg at 25°C
Appearance	Viscous Liquid or Low Melting Solid
Specific Gravity	1.303
Color	Clear colorless or white
Merck	14,6280
BRN	3591561
pKa	1.47±0.10(Predicted)
Storage Condition	2-8°C
Sensitive	Hygroscopic
Refractive Index	n20/D 1.474(lit.)
MDL	MFCD00064200
Use	Determination of absolute configuration of stereogenic carbinol carbons.

17257-71-5 - Risk and Safety

Hazard Symbols	Xi - Irritant
Risk Codes	36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S37/39 - Wear suitable gloves and eye/face protection
WGK Germany	3
FLUKA BRAND F CODES	3-10
HS Code	29189900
Hazard Note	Irritant/Keep Cold
Hazard Class	IRRITANT, HYGROSCOPI

17257-71-5 - Introduction

(S)-(-)-A-methoxy-A-(trifluoromethyl)phenylacetic acid (abbreviated as (S)-(-)-A-methoxy-A-(TFM) phenylacetic acid) it is an organic compound with the chemical formula C9H9F3O3.

Nature:
(S)-(-)-A-methoxy-A-(TFM) phenylacetic acid is A white crystalline solid with special optical activity and optical rotation. It is insoluble in water but soluble in organic solvents such as methanol, ethanol and dimethyl ether.

Use:
(S)-(-)-A-methoxy-A-(TFM) phenylacetic acid is an important chiral inducer, which is widely used in catalytic asymmetric reactions in organic synthesis. The compound is often used in the synthesis of biologically active chiral compounds, drugs and plant protection agents.

Method:
The preparation method of (S)-(-)-A-methoxy-A-(TFM) phenylacetic acid is relatively complicated. One common synthetic method is by asymmetric nucleophilic substitution catalyzed by chiral transfer catalysts.

Safety Information:
According to the current research,(S)-(-)-A-methoxy-A-(TFM) phenylacetic acid is generally relatively safe under laboratory conditions. However, as a chemical substance, it is still necessary to pay attention to safe operation and avoid contact with skin, eyes and mouth. Wear appropriate protective equipment and operate in a well-ventilated area. Any experiments and applications involving (S)-(-)-A-methoxy-A-(TFM) phenylacetic acid should follow the relevant safe practice guidelines and specifications.

Last Update：2024-04-09 19:05:47