1772-03-8

1772-03-8 - Names and Identifiers

Name	D(+)-Galactosamine hydrochloride
Synonyms	D(+)-Galactosamine h D(+)-Galactosamine HCl D(+)Galactosamine, HCl Chondrosamine hydrochloride D-Glactosamine Hydrochloride Chondrosamine, hydrochloride D-Galactosamine hydrochloride D-Chondrosamine hydrochloride D(+)Galactosamine hydrochloride D(+)-Galactosamine hydrochloride D(+)-Galactosamine Hydrochloride D-(+)-Galactosamine, hydrochloride D-GALACTOSAMINE HYDROCHLORIDE extrapure 2-ammonio-2-deoxy-beta-D-galactopyranose 2-ammonio-2-deoxy-alpha-D-galactopyranose 2-amino-2-deoxyhexopyranose hydrochloride 2-Amino-2-deoxy-D-galactose hydrochloride 2-Amino-2-deoxy-D-galactopyranose hydrochloride 2-amino-2-deoxy-alpha-D-galactopyranose hydrochloride (2R,3R,4R,5R)-2-Amino-3,4,5,6-tetrahydroxyhexanal hydrochloride 2-Amino-2-deoxy-D-galactopyranose hydrochloride, D-Chondrosamine hydrochloride, Chondrosamine
CAS	1772-03-8
EINECS	217-198-1
InChI	InChI=1/C6H13NO5.ClH/c7-3-5(10)4(9)2(1-8)12-6(3)11;/h2-6,8-11H,1,7H2;1H/t2-,3-,4+,5-,6+;/m1./s1

1772-03-8 - Physico-chemical Properties

Molecular Formula	C6H14ClNO5
Molar Mass	215.63
Density	1.3965 (rough estimate)
Melting Point	182-185°C (dec.)(lit.)
Boling Point	449.9°C at 760 mmHg
Specific Rotation(α)	96 º (589nm c=1,H2O,24 hrs)
Flash Point	225.9°C
Water Solubility	SOLUBLE
Solubility	Soluble to water
Vapor Presure	5.53E-10mmHg at 25°C
Appearance	White powder
Color	White to Off-White
Merck	14,4334
BRN	3697825
Storage Condition	room temp
Stability	Moisture Sensitive
Sensitive	Hygroscopic
Refractive Index	96 ° (C=1, H2O)
MDL	MFCD00135830
Physical and Chemical Properties	melting point 182-185°C (dec.)(lit.) specific optical rotation 96 ° (589nm c = 1, H2O,24 hrs) refractive index 96 ° (C = 1, H2O) storage conditions Store at 2-8 solubility H2O: 50 mg/mL, clear, colorless SOLUBLE in water sensitive hygropic Merck 14,4334 BRN 3697825

1772-03-8 - Risk and Safety

Hazard Symbols	Xi - Irritant
Risk Codes	36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S27 - Take off immediately all contaminated clothing. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
WGK Germany	3
RTECS	LW5500000
FLUKA BRAND F CODES	3-10
TSCA	Yes
HS Code	29329970

1772-03-8 - Reference

Reference

1. Zhang Xuan, Tang Xiaoyun, Tang Chun, Silverstone, Wang Huiqi, Zhang Xiaodong, Shen Haiping, Yang Chunhui. Effect of Chibai Decoction on Intestinal Flora of Mice with Acute Liver Failure Induced by D-Galactosamine [J]. Journal of Practical Hepatology 2019 22(04):478-481.
2. Li Yuanhui, Huang Ting, Zhang Guo Shengqi, et al. Protective effect of flaxseed extract on acute liver injury induced by D-galactosamine in mice [J]. Chinese Journal of Experimental Prescribes 2015(16):139-142.
3. Yu Huanghe, Tan Xiaowen, Yang Zhen, Zou Junju, Han Hui, Zeng Rong, Wang Wei. Protective effect of alcohol extract of Schisandra heterotype on acute liver injury induced by D-galactosamine/lipopolysaccharide in mice [J]. Chinese Journal of Hospital Pharmacy, 2017,37(11):1009-1013.
4. Shang Xiaohui, Qu Chenlong, Zhang Jianpeng, et al. Extraction of sea urchin chitosan and high performance liquid phase analysis of PMP pre-column derivatization [J]. Shi Zhen Guo Yi Guo Yao, 2015(04):830-832.
5. Li Zhaowei, Lu Qiuna, Qi Liangyu, Yang Wenlin, Zero Xinlan, wei Jiahe, Huang Yanfeng, Feng Xueping. Protective effect of cicada slough water extract on acute liver injury caused by D-galactosamine in mice [J]. Hubei Agricultural Sciences, 2017,56(12):2313-2315 2323.
6. Liang Huayi, Huang Lijuan, Nong Shengbin, et al. Preventive protective effect of phellodendron extract on acute liver injury induced by D-galactosamine in mice [J]. Guangxi Medicine, 2018, 040(003):303-305,313.
7. Gong Ruize, Wang Yanhua, Qi Yuli, etc. Effects of different processing methods on the content of water-soluble polysaccharide and monosaccharide composition in pilose antler [J]. Chromatography, 2019, 37(02):82-88.
8. Liu Songxin, Gong Ruize, Wang Zeshuai, Zhang Lei, Liu Chang, Lu Yushun, Sun Yinshi. Comparative study on 9 chemical components of pilose antler and pilose antler based on principal component analysis and discriminant analysis [J]. Chinese herbal medicine, 2021,52(01):82-90.
9. [IF = 9.381] Zhen Lin et al."Effects of a sulfated glycosaminoglycan from Sepia esculenta ink on transcriptional and metabolic profiles of Saccharomyces cerevisiae." Carbohyd Polym. 2022 Jan;276:118715
10. [IF = 4.411] Datong Hu et al.Purification, Structural Characterization, and Anti-Inflammatory Effects of a Novel Polysaccharide Isolated from Orostachys fimbriata.Molecules. 2021 Jan;26(23):7116
11. [IF = 4.451] Lan Yang et al."Prebiotic properties of Ganoderma lucidum polysaccharides with special enrichment of Bacteroides ovatus and B. uniformis in vitro." Journal of Functional Foods. 2022 May;92:105069

1772-03-8 - Reference Information

EPA chemical information	Information provided by: ofmpub.epa.gov (external link)
Use	2-amino-2-deoxy-D-galactose hydrochloride prevents COX-2 N-glycosylation and increases the conversion of COX-2 protein in a proteasome-dependent manner, and specifically inhibits COX-2. Used for biochemical research. A substrate for determination of monoamine oxidase activity in aromatic amine N-methyltransferase and tissue homogenate.
Application	2-amino-2-deoxy-D-galactose hydrochloride, also known as D-galactosamine hydrochloride, is an interfering agent of hepatocyte nucleoside metabolism and can continuously damage liver cells. It is mainly used for the study of liver pathology and biochemistry. The hepatitis model copied with it is close to the pathological changes of human hepatitis, it is reliable and useful for screening and studying anti-hepatitis drugs.
biological activity	galactosamine (D-GalN) is synthesized from galactose and is a potential liver poison. The combination of D-GalN and lipopolysaccharide can lead to fatal liver injury and liver failure. It sensitizes cells to the toxic effects of cytokines, especially tumor necrosis factor (TNF).
preparation	a preparation process of D-galactosamine hydrochloride, 500ml of anhydrous ethanol is added to a 1000ml three-mouth flask with reflux condenser tube, stirred at room temperature and added 100g of dimethyl twelve alkyl amine and 500g of solid phase silica respectively, and the temperature is raised to 110 ℃ within 30 minutes, after 5 hours of reflux reaction, it was reduced to 29 ℃, and 589g of organic amine supported catalyst was obtained by filtration and drying. add 190 g5-methyltryptamine hydrochloride and 600ml dimethylamide into a 1000ml three-mouth flask with a stirrer and a thermometer respectively, add 59g organic amine solid-supported catalyst and 150g chloropropene, react for 8 hours at room temperature, filter the reaction liquid, evaporate the obtained filtrate to dry, dissolve with 1150ml isopropanol, add 89ml 36wt% hydrochloric acid for hydrochloric acid, 130.32g of 2-amino -2-deoxy-D-galactose hydrochloride white crystal was obtained with 42.05% yield.

Last Update：2024-04-09 20:49:11