1783-84-2
CIS-8,11,14-EICOSATRIENOIC ACID
CAS: 1783-84-2
Molecular Formula: C21H36O2
1783-84-2 - Names and Identifiers
1783-84-2 - Physico-chemical Properties
| Molecular Formula | C21H36O2 |
| Molar Mass | 320.51 |
| Density | 0.917±0.06 g/cm3(Predicted) |
| Boling Point | 200°C(lit.) |
| Flash Point | 144 °F |
| Appearance | Liquid |
| Storage Condition | 2-8℃ |
| Refractive Index | n20/D 1.478(lit.) |
| Physical and Chemical Properties | Bioactive Dihomo-γ-linolenic acid (all-cis-8,11,14-Eicosatrienoic acid) is a 20-carbon omega -6 fatty acid with anti-inflammatory and anti-proliferative activities. Dihomo-γ-linolenic acid attenuates atherosclerosis in an apolipoprotein E-deficient mouse model. |
1783-84-2 - Risk and Safety
| Safety Description | S23 - Do not breathe vapour. S24/25 - Avoid contact with skin and eyes. |
| UN IDs | NA 1993 / PGIII |
1783-84-2 - Security information
| WGK Germany | 3 |
| RTECS number | JX3880000 |
| F | 8-10-23 |
Last Update：2024-04-10 22:29:15
1783-84-2 - Uses and synthesis methods
target
Human Endogenous Metabolite
in vitro study
Dihomo-γ-linolenic acid attenuates pro-inflammatory gene expression in human and mouse macrophages.
Dihomo-γ-linolenic acid (50 μM; 24 hours) attenuates IFN-γ induced phosphorylation of STAT1 on serine 727.
Dihomo-γ-linolenic acid attenuates IL-1β and TNF-α induced MCP-1 and ICAM-1 expression in human macrophages.
Dihomo-γ-linolenic acid attenuates chemokine-driven monocytic migration and macrophage foam cell formation.
Dihomo-γ-linolenic acid attenuates the expression of SR-A and CD36 in human macrophages.
Dihomo-γ-linolenic acid modulates mitochondrial respiration.
Dihomo-γ-linolenic acid modulates the properties of endothelial cells and VSMC.
Western Blot Analysis
Cell Line: THP-1 macrophages
Concentration: 50 μM (pre-treated)
Incubation Time: 24 hours
Result: Attenuated IFN-γ induced phosphorylation of STAT1 on serine 727.
in vivo studies
Dihomo-γ-linolenic acid (8 mg/mouse; I .g; twice a week; for 35 days) inhibits growth of xenograft tumors in mice bearing human pancreatic cancer cells (BxPC-3) transfected with delta-5-desaturase shRNA.
Animal Model: Female nude mice (48 four-week old)
Dosage: 8 mg/mouse
Administration: Oral gavage, twice a week, for 35 days
Result: Suppressed metastasis potential in D5D-KD tumors.
Last Update：2024-04-09 21:54:55
1783-84-2 - Nature
| storage conditions | -20°C |
| solubility | chloroform: 50 mg/mL, clear, colorless |
| acidity coefficient (pKa) | 4.77±0.10(Predicted) |
| morphology | Liquid |
| BRN | 1796533 |
Last Update：2024-04-09 20:45:29
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Spot supply
Product Name: 8Z,11Z,14Z-Eicosatrienoic Acid Visit Supplier Webpage Request for quotationCAS: 1783-84-2
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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