1800405-30-4

Name	NQO1 activator 1
Synonyms	KL1333 KL-1333 NQO1 activator 1 NQO1 ACTIVATOR 1 KL-1333(NQO1 activator 1) 2-(1-Methylethyl)-3H-naphth[1,2-d]imidazole-4,5-dione 3H-Naphth[1,2-d]imidazole-4,5-dione, 2-(1-methylethyl)-
CAS	1800405-30-4

Molecular Formula	C14H12N2O2
Molar Mass	240.26
Density	1.329±0.06 g/cm3(Predicted)
Boling Point	517.3±19.0 °C(Predicted)
Solubility	DMSO : 250 mg/mL (1040.54 mM; Need ultrasonic)
pKa	8.58±0.20(Predicted)
Storage Condition	-20°C
In vitro study	KL1333 is a potent modulator of the cellular levels of NAD⁺, a central co-enzyme in the cell’s energy metabolism. Elevated NAD+ levels triggers the activation of SIRT1 and AMPK, and subsequently activates PGC-1α.

Last Update：2024-01-02 23:10:35

biological activity	KL1333 is an oral NAD modulator, and NAD(P)H: quinone oxidoreductase 1 (NQO1) reacts as a substrate, leading to increased intracellular NAD levels through NADH oxidation. Elevated NAD levels trigger activation of SIRT1 and AMPK, and subsequent activation of PGC-1α. KL1333 improves energy metabolism and mitochondrial dysfunction in mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) fibroblasts. Protection of KL1333 against cisplatin-induced ototoxicity in mouse cochlear cultures.
Target	NQO1
Animal Model:	db/db mice
Dosage:	80 mg/kg
Administration:	P.o.; daily for 15 weeks
Result:	Activated AMPK and SIRT1.

Last Update：2024-04-09 20:48:19

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1800405-30-4

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