1801433-90-8
2-Propen-1-one, 1-(4,6-dimethoxy-1,3-benzodioxol-5-yl)-2-(2-hydroxyphenyl)-
CAS: 1801433-90-8
Molecular Formula: C18H16O6
1801433-90-8 - Names and Identifiers
| Name | 2-Propen-1-one, 1-(4,6-dimethoxy-1,3-benzodioxol-5-yl)-2-(2-hydroxyphenyl)- |
| Synonyms | Biliatresone 2-Propen-1-one, 1-(4,6-dimethoxy-1,3-benzodioxol-5-yl)-2-(2-hydroxyphenyl)- |
| CAS | 1801433-90-8 |
1801433-90-8 - Physico-chemical Properties
| Molecular Formula | C18H16O6 |
| Molar Mass | 328.32 |
| In vitro study | Biliatresone has a reduction in primary cilia and a dose-dependent decrease in visible microtubules, suggesting that Biliatresone decreases microtubule stability in primary neonatal mouse extrahepatic cholangiocytes. Biliatresone (2 µg/ml; for 24 hours) shows disruption of the spheroid lumen and abnormal cholangiocyte polarity in mouse cholangiocyte. |
| In vivo study | Biliatresone exhibits toxicity at doses of 0.065-1.0 μg/mL with a marked reduction and the lethal dose of Biliatresone in a zebrafish assay is 1 μg/mL. Larvae treated at 5 dpf with low doses of biliatresone [0.0625 µg/ml (0.2 µM) and 0.125 µg/ml (0.4 µM)] shows only subtle gallbladder defects, whereas larvae treated with higher doses has pronounced morphological defects of the gallbladder and extrahepatic ducts. |
1801433-90-8 - Reference Information
| biological activity | Biliatresone is a natural toxin isolated from glomulifera and d littoralis Dysphania of coccidioides. Biliatresone is a 1, 2-diaryl-2-acetone isoflavone that produces extrahepatic biliary atresia in zebrafish models. |
| in vitro study | Biliatresone has a reduction in primary cilia and a dose-dependent decrease in visible microtubules, suggesting that Biliatresone decreases microtubule stability in primary neonatal mouse extrahepatic cholangiocytes. Biliatresone (2 µg/ml; for 24 hours) shows disruption of the spheroid lumen and abnormal cholangiocyte polarity in mouse cholangiocyte. |
| in vivo study | Biliatresone exhibits toxicity at doses of 0.065-1.0 μ g/ml with a marked reduction and the left dose of Biliatresone in a zebrafish assay is 1 μ g/ml. larvae treated at 5 dpf with low doses of biliatresone [0.0625g/ml (0.2 m) and 0.125g/ml (0.4 m)] shows only subtle gallbladder defects, whereas larvae treated with higher dos has pronounced morphological defects of the gallbladder and extrahepatic ducts. |
Last Update：2024-04-09 21:04:16
