1801863-88-6
(4E)-TCO-PEG4-DBCO
CAS: 1801863-88-6
Molecular Formula: C38H49N3O8
1801863-88-6 - Names and Identifiers
| Name | (4E)-TCO-PEG4-DBCO |
| Synonyms | TCO-PEG4-DBCO (4E)-TCO-PEG4-DBCO |
| CAS | 1801863-88-6 |
1801863-88-6 - Physico-chemical Properties
| Molecular Formula | C38H49N3O8 |
| Molar Mass | 675.82 |
| Density | 1.22±0.1 g/cm3(Predicted) |
| Boling Point | 891.1±65.0 °C(Predicted) |
| pKa | 11.95±0.46(Predicted) |
| Storage Condition | -20°C |
| In vitro study | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. |
1801863-88-6 - Introduction
(4E)-TCO-PEG4-DBCO, also known as tetraethylene glycol tetramethyletheryl diphenylacetimine (4E)-Nickel (II) salt, is an organic compound. Its properties are as follows:
1. Appearance: white or white solid.
2. Molecular formula: C36H43N3NiO14
3. Molecular weight: 821.32g/mol
4. Melting Point: about 140-150 ℃ (decomposition)
5. Solubility: Soluble in organic solvents, such as dimethyl sulfide and chloroform.
(4E)-TCO-PEG4-DBCO are mainly used in click chemistry reactions in the field of chemical biology for the synthesis of biomolecules with specific functions, including drug delivery systems, nanoparticle labeling, and biosensors. Its unique structure allows it to have efficient click reactions with other compounds containing DBCO (dichloroanilinoformimide) functional groups, thereby achieving flexible chemical coupling and modification.
The method of preparing (4E)-TCO-PEG4-DBCO is relatively complex and generally requires organic synthesis techniques and equipment. The specific preparation method can refer to the relevant scientific literature or patent.
With regard to safety information, the toxicity and safety assessment of (4E)-TCO-PEG4-DBCO is limited due to the lack of specific information. When handling and using chemical reagents, regular laboratory safety practices should be followed, including wearing appropriate protective gloves and safety glasses to ensure that the operation is carried out under well-ventilated conditions, avoid skin contact and inhalation. If it is necessary to use this compound, please refer to the relevant literature for further safety information and operational recommendations.
1. Appearance: white or white solid.
2. Molecular formula: C36H43N3NiO14
3. Molecular weight: 821.32g/mol
4. Melting Point: about 140-150 ℃ (decomposition)
5. Solubility: Soluble in organic solvents, such as dimethyl sulfide and chloroform.
(4E)-TCO-PEG4-DBCO are mainly used in click chemistry reactions in the field of chemical biology for the synthesis of biomolecules with specific functions, including drug delivery systems, nanoparticle labeling, and biosensors. Its unique structure allows it to have efficient click reactions with other compounds containing DBCO (dichloroanilinoformimide) functional groups, thereby achieving flexible chemical coupling and modification.
The method of preparing (4E)-TCO-PEG4-DBCO is relatively complex and generally requires organic synthesis techniques and equipment. The specific preparation method can refer to the relevant scientific literature or patent.
With regard to safety information, the toxicity and safety assessment of (4E)-TCO-PEG4-DBCO is limited due to the lack of specific information. When handling and using chemical reagents, regular laboratory safety practices should be followed, including wearing appropriate protective gloves and safety glasses to ensure that the operation is carried out under well-ventilated conditions, avoid skin contact and inhalation. If it is necessary to use this compound, please refer to the relevant literature for further safety information and operational recommendations.
Last Update：2024-04-09 19:05:03
