180258-96-2
2-(1-Adamantyl)pyrrolidine
CAS: 180258-96-2
Molecular Formula: C14H23N
180258-96-2 - Names and Identifiers
| Name | 2-(1-Adamantyl)pyrrolidine |
| Synonyms | 2-(1-Adamantyl)pyrrolidine 2-(1-Adamantyl)pyrrolidine, HCl Pyrrolidine, 2-tricyclo[3.3.1.13,7]dec-1-yl- |
| CAS | 180258-96-2 |
180258-96-2 - Physico-chemical Properties
| Molecular Formula | C14H23N |
| Molar Mass | 205.34 |
| Density | 1.066±0.06 g/cm3(Predicted) |
| Boling Point | 289.8±8.0 °C(Predicted) |
| pKa | 11.24±0.10(Predicted) |
| Storage Condition | Room Temprature |
| Sensitive | Irritant |
| MDL | MFCD02663498 |
180258-96-2 - Introduction
2-(1-Adamantyl)pyrrolidine (2-(1-Adamantyl)pyrrolidine) is an organic compound with the chemical formula C12H21N. It has the physical state of a solid, colorless to pale yellow crystals. The following is a description of its nature, use, preparation and safety information:
Nature:
-Appearance: Colorless to light yellow crystal
-Solubility: Can be dissolved in common organic solvents, such as alcohols, ketones and esters. It is poorly soluble in water.
-Melting point: about 75-80 degrees Celsius.
Use:
- 2-(1-Adamantyl)pyrrolidine is a commonly used organic synthesis intermediate, which is widely used in the field of pharmaceutical synthesis and organic synthesis.
-It can be used to synthesize biologically active compounds, such as drugs in the field of medicine.
Preparation Method:
The preparation method of -2-(1-Adamantyl)pyrrolidine can be carried out by the following steps:
1. First, 1-iminooctane is reacted with dimethyl phthalate to produce dimethyl 2-iminooctane dicarboxylate.
2. Reaction of dimethyl 2-iminooctane dicarboxylate with isoniacic anhydride to give 2-(1-iminooctyl)-1H-pyrrole.
3. Finally, 2-(1-iminooctyl)-1H-pyrrole is converted to 2-(1-Adamantyl)pyrrolidine by hydrogen hydrogenation.
Safety Information:
- 2-(1-Adamantyl)pyrrolidine has not been included in the list of particularly hazardous substances. However, as a chemical substance, the following safety precautions should be paid attention to when using:
-Avoid direct contact with skin and eyes during operation to prevent inhalation and accidental ingestion.
-Wear personal protective equipment such as protective gloves, safety goggles and protective masks when using.
-After use, residues and waste should be stored and disposed of properly, following local waste disposal regulations.
Please note that the above information is for reference only. Please refer to the laboratory safety operation manual and related materials for specific use and operation.
Nature:
-Appearance: Colorless to light yellow crystal
-Solubility: Can be dissolved in common organic solvents, such as alcohols, ketones and esters. It is poorly soluble in water.
-Melting point: about 75-80 degrees Celsius.
Use:
- 2-(1-Adamantyl)pyrrolidine is a commonly used organic synthesis intermediate, which is widely used in the field of pharmaceutical synthesis and organic synthesis.
-It can be used to synthesize biologically active compounds, such as drugs in the field of medicine.
Preparation Method:
The preparation method of -2-(1-Adamantyl)pyrrolidine can be carried out by the following steps:
1. First, 1-iminooctane is reacted with dimethyl phthalate to produce dimethyl 2-iminooctane dicarboxylate.
2. Reaction of dimethyl 2-iminooctane dicarboxylate with isoniacic anhydride to give 2-(1-iminooctyl)-1H-pyrrole.
3. Finally, 2-(1-iminooctyl)-1H-pyrrole is converted to 2-(1-Adamantyl)pyrrolidine by hydrogen hydrogenation.
Safety Information:
- 2-(1-Adamantyl)pyrrolidine has not been included in the list of particularly hazardous substances. However, as a chemical substance, the following safety precautions should be paid attention to when using:
-Avoid direct contact with skin and eyes during operation to prevent inhalation and accidental ingestion.
-Wear personal protective equipment such as protective gloves, safety goggles and protective masks when using.
-After use, residues and waste should be stored and disposed of properly, following local waste disposal regulations.
Please note that the above information is for reference only. Please refer to the laboratory safety operation manual and related materials for specific use and operation.
Last Update：2024-04-09 21:01:54
