180288-69-1
Trastuzumab
CAS: 180288-69-1
Molecular Formula: C10H14N6O5
180288-69-1 - Names and Identifiers
180288-69-1 - Physico-chemical Properties
| Molecular Formula | C10H14N6O5 |
| Molar Mass | 298.25536 |
| Storage Condition | -20°C |
| In vitro study | Trastuzumab (anti-HER2) exerts specific antitumor activity in tumor cells overexpressing HER2. Trastuzumab binds to the near-membrane region of HER2, and once bound to the receptor, this antibody down-regulates HER2 expression. Trastuzumab selectively inhibits ligand-independent HER2-HER3 dimerization. In addition, the binding of trastuzumab to HER2 inhibits proteolytic cleavage of the extracellular domain of HER2, resulting in reduced p95-HER2 levels. trastuzumab can cause the PI3K signaling pathway and downstream cell cycle progression related mediators such as cyclin D1. Trastuzumab not only inhibits the HER2 signaling pathway, but also causes immune-related responses in HER2 overexpressing cells. Binding of Trastuzumab occupies the Fc receptor on immune effector cells, resulting in antibody-dependent cytotoxicity. Thus, trastuzumab has anti-angiogenic effects and lowers the threshold for apoptosis in chemotherapy. |
| In vivo study | Trastuzumab was demonstrated to be safe by chronic administration of Trastuzumab in a range of animal models, including primates. In adjunctive therapy experiments simulating submacroscopic disease, trastuzumab was able to inhibit the growth of macroscopic detectable xenografts for 5-7 weeks. Trastuzumab has significant anti-tumor activity and is currently being used in the treatment of breast cancer. In an in vivo model, trastuzumab reduces microvessel density in breast cancer xenografts. Trastuzumab acts directly on cancer cell signals and indirectly on the immune system. |
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CAS: 180288-69-1
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Product Name: Trastuzumab Visit Supplier Webpage Request for quotation
CAS: 180288-69-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
CAS: 180288-69-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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