1818389-84-2
SPHINX31
CAS: 1818389-84-2
Molecular Formula: C27H24F3N5O2
1818389-84-2 - Names and Identifiers
| Name | SPHINX31 |
| Synonyms | CS-2837 SPHINX31 2-Furancarboxamide, 5-(4-pyridinyl)-N-[2-[4-(2-pyridinylmethyl)-1-piperazinyl]-5-(trifluoromethyl)phenyl]- |
| CAS | 1818389-84-2 |
1818389-84-2 - Physico-chemical Properties
| Molecular Formula | C27H24F3N5O2 |
| Molar Mass | 507.51 |
| Density | 1.342±0.06 g/cm3(Predicted) |
| Boling Point | 569.0±50.0 °C(Predicted) |
| pKa | 11.83±0.70(Predicted) |
| Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
| In vitro study | The kinase assay demonstrated that SPHINX31 is a competitive inhibitor of ATP. Treatment of PC3 cancer cells with 300 nM SPHINX31 resulted in inhibition of SRSF1 phosphorylation. Metabolic stability testing in mouse liver microsomes found that SPHINX31 had a moderate clearance with a T 1/2 of 95.79 min. Inhibition of SRPK1 with SPHINX31 can cause cell cycle arrest and leukemic cell differentiation. |
| In vivo study | SPHINX31 can penetrate into the eye. In a mouse model, SPHINX31 exerts a concentration-dependent inhibitory effect on choroidal neovascularization. SPHINX31 inhibits vascular growth and macrophage infiltration. The administration of SPHINX31 prolonged the survival time of immunocompromised mice transplanted with MLL-rearranged AML cells. |
1818389-84-2 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 1.97 ml | 9.852 ml | 19.704 ml |
| 5 mM | 0.394 ml | 1.97 ml | 3.941 ml |
| 10 mM | 0.197 ml | 0.985 ml | 1.97 ml |
| 5 mM | 0.039 ml | 0.197 ml | 0.394 ml |
Last Update：2024-01-02 23:10:35
1818389-84-2 - Introduction
SPHINX31 is an organic compound with the specific name 3,3 '-dimethyl -1,1'-diphenylacetone. The following is a description of the nature, use, preparation and safety information of SPHINX31:
Nature:
SPHINX31 is a colorless crystalline solid with high melting point and stability. It is almost insoluble in water at room temperature, but soluble in organic solvents. Its chemical structure gives it very stable chemical properties.
Use:
SPHINX31 is commonly used as a catalyst or reagent in organic synthesis. It can catalyze a variety of organic conversion reactions such as hydrogenation, carbonylation, and cyclization. In addition, SPHINX31 can also be used in the synthesis of organic compounds with special structures or properties, such as the synthesis of chiral compounds.
Preparation Method:
Generally, SPHINX31 is synthesized by a two-step reaction. First, Styrene is converted to 3,3 '-diphenylacetone via a series of reactions. 3,3 '-diphenylacetone is then reacted with a methyl nickel complex to produce sphinx31.
Safety Information:
When using SPHINX31, attention should be paid to its potential risks to health and the environment. It may cause irritation to the skin, eyes and respiratory tract. Therefore, protective gloves, goggles and gas masks should be worn during operation. In addition, it should be operated in a well-ventilated place to avoid contact with open flames and to avoid inhaling its dust. For specific safety practice guidelines, refer to the safety data sheets of the relevant chemicals on a case-by-case basis.
Nature:
SPHINX31 is a colorless crystalline solid with high melting point and stability. It is almost insoluble in water at room temperature, but soluble in organic solvents. Its chemical structure gives it very stable chemical properties.
Use:
SPHINX31 is commonly used as a catalyst or reagent in organic synthesis. It can catalyze a variety of organic conversion reactions such as hydrogenation, carbonylation, and cyclization. In addition, SPHINX31 can also be used in the synthesis of organic compounds with special structures or properties, such as the synthesis of chiral compounds.
Preparation Method:
Generally, SPHINX31 is synthesized by a two-step reaction. First, Styrene is converted to 3,3 '-diphenylacetone via a series of reactions. 3,3 '-diphenylacetone is then reacted with a methyl nickel complex to produce sphinx31.
Safety Information:
When using SPHINX31, attention should be paid to its potential risks to health and the environment. It may cause irritation to the skin, eyes and respiratory tract. Therefore, protective gloves, goggles and gas masks should be worn during operation. In addition, it should be operated in a well-ventilated place to avoid contact with open flames and to avoid inhaling its dust. For specific safety practice guidelines, refer to the safety data sheets of the relevant chemicals on a case-by-case basis.
Last Update：2024-04-09 21:01:54
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Product Name: SPHINX31 Visit Supplier Webpage Request for quotationCAS: 1818389-84-2
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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