18296-44-1

Name	Valtrate
Synonyms	Valtrate ValtratuM 18296-44-1 VALTRATE(P) ValepotriatuM Valtrate [INN] Halazuchrome B HalazuchroMe B VALTRATE(P)(PLEASE CALL) (1S,7R)-4-Acetoxymethyl-6,7aα-dihydrospiro[cyclopenta[c]pyran-7(1H),2'-oxirane]-1α,6α-diol 1,6-bis(3-methylbutanoate) (1S,6S,7R,7aS)-4-(Acetoxymethyl)-6,7a-dihydro-1H-spiro[cyclopenta[c]pyran-7,2'-oxirane]-1,6-diyl bis(3-methylbutanoate) (1S,6S,7aS)-4-[(acetyloxy)methyl]-6,7a-dihydro-1H-spiro[cyclopenta[c]pyran-7,2'-oxirane]-1,6-diyl bis(3-methylbutanoate) (1S,6S,7R,7aS)-4-[(acetyloxy)methyl]-6,7a-dihydro-1H-spiro[cyclopenta[c]pyran-7,2'-oxirane]-1,6-diyl bis(3-methylbutanoate) butanoic acid, 3-methyl-, (1S,6S,7R,7aS)-4-[(acetyloxy)methyl]-6,7a-dihydrospiro[cyclopenta[c]pyran-7(1H),2'-oxirane]-1,6-diyl ester (1S-(1a,6a,7b,7aa))-3-Methylbutanoic Acid 4-((Acetyloxy)methyl)-6,7a-dihydrospiro(cyclopenta[c]pyran-7(1H),2'-oxirane)-1,6-diyl Ester [(1S,6S,7aS)-4-(Acetyloxymethyl)-1-(3-methylbutanoyloxy)spiro[6,7a-dihydro-1H-cyclopenta[c]pyran-7,2'-oxirane]-6-yl] 3-methylbutanoate
CAS	18296-44-1
EINECS	242-174-2
InChI	InChI=1/C22H30O8/c1-12(2)6-18(24)29-17-8-16-15(9-26-14(5)23)10-27-21(20(16)22(17)11-28-22)30-19(25)7-13(3)4/h8,10,12-13,17,20-21H,6-7,9,11H2,1-5H3/t17-,20+,21-,22?/m0/s1

Molecular Formula	C22H30O8
Molar Mass	422.47
Density	1.22±0.1 g/cm3(Predicted)
Boling Point	525.9±50.0 °C(Predicted)
Specific Rotation(α)	+172.7 (MeOH)
Flash Point	226.5°C
Solubility	Soluble in methanol, ethanol, DMSO and other organic solvents
Vapor Presure	3.75E-11mmHg at 25°C
Appearance	Yellow liquid
Color	Pale Brown to Dark Yellow to Sticky
Storage Condition	Refrigerator
Refractive Index	1.528
MDL	MFCD00868024
Physical and Chemical Properties	Yellow liquid, soluble in methanol, ethanol, DMSO and other organic solvents, derived from spider fragrance, valerian.
In vivo study	Valepotriateshowed significant anti-epileptic activity against MES- and PTZ-induced epilepsy at doses of 5, 10, and 20 mg/kg, and ED50values for MES- and PTZ-induced epilepsy were 7.84 and 7.19 mg/kg, respectively. Furthermore,valepotriate(10 and 20 mg/kg) can significantly prolong sleeping time and shorten the latency time on the pentobarbital sodium-induced sleeping time test. Furthermore,valepotriate(5, 10, and 20 mg/kg) could significantly up-regulate the expression of GABAA, GAD65, and Bcl-2 and down-regulate the expression of caspase-3, but had no significant effect on the expression of GABAB.

HS Code

29329990

biological activity	Valepotriate, isolated from Valeriana jatamansi, has anti-epileptic and anti-cancer activities.
in vivo study	Valepotriateshowed significant anti-epileptic activity against MES- and PTZ-induced epilepsy at doses of 5, 10, and 20 mg/kg, and ED50values for MES- and PTZ-induced epilepsy were 7.84 and 7.19 mg/kg, respectively. Furthermore,valepotriate(10 and 20 mg/kg) can significantly prolong sleeping time and shorten the latency time on the pentobarbital sodium-induced sleeping time test. Furthermore,valepotriate(5, 10, and 20 mg/kg) could significantly up-regulate the expression of GABAA, GAD65, and Bcl-2 and down-regulate the expression of caspase-3, but had no significant effect on the expression of GABAB.
chemical properties	yellow liquid, soluble in organic solvents such as methanol, ethanol, DMSO, etc., derived from spider fragrance and valerian.
use	valerian triester has anti-tumor and anti-senile dementia effects. used for content determination/identification/pharmacological experiment, etc.

Last Update：2024-04-09 21:04:16

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18296-44-1

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