183742-34-9

183742-34-9 - Names and Identifiers

Name	4-Boc-1-Fmoc-2-Piperazine acetic acid
Synonyms	1-Fmoc-4-Boc-2-piperazineacetic Acid 1-FMOC-4-BOC-PIPERAZINE-2-ACETIC ACID 4-Boc-1-Fmoc-2-Piperazine acetic acid N-4-BOC-N-1-FMOC-2-PIPERAZINE ACETIC ACID 1-N-FMOC-4-N-BOC-PIPERAZINE-2-ACETIC ACID (R)-N-1-BOC-N-4-FMOC-2-PIPERAZINE CARBOXYLIC ACID 4-[(9H-FLUOREN-9-YLOXY)CARBONYL]-1-(TERT-BUTOXYCARBONYL)PIPERAZYL-2-ACETIC ACID {4-(tert-butoxycarbonyl)-1-[(9H-fluoren-9-ylmethoxy)carbonyl]piperazin-2-yl}acetic acid {(2S)-4-(tert-butoxycarbonyl)-1-[(9H-fluoren-9-ylmethoxy)carbonyl]piperazin-2-yl}acetate {(2R)-4-(tert-butoxycarbonyl)-1-[(9H-fluoren-9-ylmethoxy)carbonyl]piperazin-2-yl}acetate 2-CARBOXYMETHYL-PIPERAZINE-1,4-DICARBOXYLIC ACID 4-TERT-BUTYL ESTER 1-(9H-FLUOREN-9-YLMETHYL) ESTER 2-[1-(9H-Fluoren-9-ylmethoxycarbonyl)-4-[(2-methylpropan-2-yl)oxycarbonyl]piperazin-2-yl]acetic acid
CAS	183742-34-9
InChI	InChI=1/C26H30N2O6/c1-26(2,3)34-24(31)27-12-13-28(17(15-27)14-23(29)30)25(32)33-16-22-20-10-6-4-8-18(20)19-9-5-7-11-21(19)22/h4-11,17,22H,12-16H2,1-3H3,(H,29,30)/p-1/t17-/m0/s1

183742-34-9 - Physico-chemical Properties

Molecular Formula	C26H30N2O6
Molar Mass	466.53
Density	1.261±0.06 g/cm3(Predicted)
Boling Point	637.4±35.0 °C(Predicted)
Flash Point	339.3°C
Vapor Presure	4.03E-17mmHg at 25°C
pKa	4.67±0.10(Predicted)
Storage Condition	2-8°C

183742-34-9 - Risk and Safety

Safety Description

24/25 - Avoid contact with skin and eyes.

183742-34-9 - Introduction

4-Boc-1-Fmoc-2-Piperazine acetic acid is an organic compound with the following properties:

1. Appearance: A white crystalline solid.
2. Chemical structure: it is composed of 4-amino benzoic acid, Fmoc protecting group and piperazine group.
3. Solubility: It is soluble in common organic solvents such as chloroform, methanol and dimethylformamide.
4. Stability: 4-Boc-1-Fmoc-2-Piperazine acetic acid is relatively stable under regular experimental conditions.

Use:
4-Boc-1-Fmoc-2-Piperazine acetic acid is mostly used in organic synthesis and is commonly used in peptide synthesis in solid phase synthesis. It can be used as a protecting group to protect the amino group. In the solid phase synthesis, it can realize the protection and deprotection of the amino group by controlling the deprotection reaction of the substituent.

Method:
4-Boc-1-Fmoc-2-Piperazine acetic acid can be prepared by the following steps:
1. First, 4-aminobenzoic acid is condensed with piperazine acetic acid to obtain 4-(piperazinyl) benzoic acid.
2. Condensation of 4-(piperazinyl) benzoic acid with Fmoc-OSu to generate 4-Boc-1-Fmoc-2-Piperazine acetic acid.
3. Purify the product to obtain the desired compound.

Safety Information:
As an organic compound, 4-Boc-1-Fmoc-2-Piperazine acetic acid needs to pay attention to the following safety information:
1. During the operation, direct contact with skin and eyes should be avoided, because it may have irritating effects on skin and eyes.
2. Use should wear appropriate protective gloves, safety glasses and protective clothing to ensure safe operation.
3. Storage to avoid contact with oxidants, strong acids and other substances to avoid dangerous reactions.
4. Before use, please read the safety data sheet of the product carefully and follow the correct operation method. If you have any questions or emergencies, please consult a professional.

Last Update：2024-04-09 21:01:54