18609-17-1
quercetin-3-O-sophoroside
CAS: 18609-17-1
Molecular Formula: C27H30O17
18609-17-1 - Names and Identifiers
18609-17-1 - Physico-chemical Properties
| Molecular Formula | C27H30O17 |
| Molar Mass | 626.52 |
| Density | 1.89±0.1 g/cm3(Predicted) |
| Melting Point | 198-200℃ |
| Boling Point | 1037.2±65.0 °C(Predicted) |
| Specific Rotation(α) | (c, 1.77 in EtOH)-31； (c, 2.24 in Py)-136.7 |
| Solubility | Soluble in methanol, ethanol, DMSO and other organic solvents |
| Appearance | Pale yellow powder |
| Storage Condition | 2-8℃ |
| Physical and Chemical Properties | Chemical properties of white crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from apocynum venetumL.. |
| Use | Use 1, White hemp glycosides with enhanced energy, improve fertility, improve sexual function, the treatment of menopausal syndrome, rheumatism, depression, anemia role. 2, for content determination/identification/pharmacological experiments and other pharmacological effects: with enhanced energy, improve fertility, improve sexual function, treatment of menopausal syndrome, rheumatism, depression, anemia |
18609-17-1 - Reference
| Reference Show more | 1. Zhang Juan, Qing de, gang, Sun Yu, et al. Chemometrics-assisted analysis of flavonoids in apocynum venetum [J]. Northwest Pharmaceutical Journal 2020 035(002):173-177. 2. Su Zhina, Luo Weilan, Wei Rongrui, etc. Rapid identification of chemical constituents of Tibetan medicinal Urtica at Plateau based on UPLC-ESI-Q-TOF-MS/MS Technology [J]. Chinese Journal of Traditional Chinese Medicine, 2019, 29 (8). 3. Zhang Juan, Feng Chunyan, Qing Degang, etc. Study on the pharmacokinetics of the total flavonoids of D. Macrophylla [J]. Chinese national folk medicine, 2019, 28(03):24-28. 4. Hongjuan Li, Ying Liu, Yuetao Yi, Qin miao, Sujing Liu, Feng Zhao, Wei Cong, Chunhua Wang, Chuanhai Xia, Purification of quercetin-3-O-sophoroside and isoquercitrin from Poacynum hendersonii leaves using macroporous resins followed by Sephadex LH-20 column 5. [IF=5.81] Mu Jianfei et al."Determination of Polyphenols in Ilex kudingcha and Insect Tea (Leaves Altered by Animals) by Ultra-high-performance Liquid Chromatography-Triple Quadrupole Mass Spectrometry (UHPLC-QqQ-MS) and Comparison of Their Anti-Aging Effects."Fro 6. [IF=5.537] Tiantian Tang et al."A difference of enzymatic browning unrelated to PPO from physiology, targeted metabolomics and gene expression analysis in Fuji apples."Postharvest Biol Tec. 2020 Dec;170:111323 7. [IF=5.279] Yanan Gao et al."Galactosylation of Monosaccharide Derivatives of Glycyrrhetinic Acid by UDP-Glycosyltransferase GmSGT2 from Glycine max."J Agr Food Chem. 2020;68(32):8580-8588 8. [IF=4.952] Yuxin Hao et al."Stability and mechanism of phenolic compounds from raspberry extract under in vitro gastrointestinal digestion."Lwt Food Sci Technol. 2021 Mar;139:110552 9. [IF=4.952] Zhiqiang Hou et al."Processing of chestnut rose juice using three-stage ultra-filtration combined with high pressure processing."Lwt Food Sci Technol. 2021 May;143:111127 10. [IF=4.769] Yuan Hong et al."Determination of bioactive components in the fruits of Cercis chinensis Bunge by HPLC-MS/MS and quality evaluation by principal components and hierarchical cluster analyses."J Pharm Anal. 2021 Aug;11:465 11. [IF=4.599] Guo Ying et al."Temporospatial Flavonoids Metabolism Variation in Ginkgo biloba Leaves."Front Genet. 2020 Nov;0:1503 12. [IF=4.36] Mingliang Gao et al."Evaluation of VEGF mediated pro-angiogenic and hemostatic effects and chemical marker investigation for Typhae Pollen and its processed product."J Ethnopharmacol. 2021 Mar;268:113591 13. [IF=4.27] Zhikang Zhao et al."Functional analysis of PpRHM1 and PpRHM2 involved in UDP-l-rhamnose biosynthesis in Prunus persica."Plant Physiol Bioch. 2020 Oct;155:658 14. [IF=4.225] Wen Xianghui et al."Qu-Zhuo-Tong-Bi Decoction Alleviates Gouty Arthritis by Regulating Butyrate-Producing Bacteria in Mice."Front Pharmacol. 2021 Feb;11:2508 15. [IF=3.978] Yunbin Lyu et al."Identification and characterization of three flavonoid 3-O-glycosyltransferases from Epimedium koreanum Nakai."Biochem Eng J. 2020 Nov;163:107759 16. [IF=3.659] Hu Yucheng et al."Regulation effects of total flavonoids in Morus alba L. on hepatic cholesterol disorders in orotic acid induced NAFLD rats."Bmc Complem Altern M. 2020 Dec;20(1):1-12 17. [IF=3.645] Jie Lu et al."Identification and determination of chemical constituents from Yinchen Qingjin granules by ultra high-performance liquid chromatography coupled with linear ion trap-Orbitrap mass spectrometry."J Sep Sci. 2021 Apr;44(7):1324-1344 18. [IF=3.368] Jingyuan Wang et al."Human small intestine cancer cell membrane-camouflaged quercetin-melanin for antibacterial and antitumor activity."J Biomed Mater Res B. 2021 Oct;109(10):1534-1551 |
18609-17-1 - Study on the pharmacokinetics of the total flavonoids in the leaves of white hemp
from VIP Journal Professional Edition
Author:
Zhang Juan , Feng Chunyan , Qing de gang , Sun Yu , Xu Xiaoqin , Ni hui
Abstract:
objective: to establish a HPLC method for the determination of the content of the content of the HPLC in rat plasma, and to investigate the pharmacokinetic characteristics of the in vivo. Methods: XTARRA RP18 column, acetonitrile -0. 2% Phosphoric acid aqueous solution gradient elution, 35 ℃,1 m L/min,360 nm detection. Six male SD rats were given 1. 05g/Kg total flavonoids, determination of different dosing time points, animal plasma concentration of white hemp glycosides, and its pharmacokinetic parameters were studied. Results: the content of glycoside was 0. 0606~19. 4040 mg/L range of good linear relationship (R = 0. 9996), the relative recoveries of low, medium and high concentration samples were 102. 29%,92. 95%,90. 11%, intra-day RSD were 1. 53%,1. 07%,3. 62%, daytime RSD were 8. 33%,3. 56%,4. 03%. After gavage of total flavonoids from P. Macrophylla in rats, the metabolic process of glycoside in rats conforms to the open two-compartment model, and the elimination half-life is 474. 13 min. Conclusion: the distribution of the glycoside in rats is rapid and the duration is long.
stowed
Key words:
C. Macrophylla; C. Glycoside; HPLC; pharmacokinetics
DOI:
CNKI:SUN:MZMJ.0.2019-03-008
year:
2019
Last Update：2024-01-02 23:10:35
18609-17-1 - A method for the simultaneous separation of glycoside, isosorbiin and chlorogenic acid from the leaves of B. Macrophylla
Application (patent) number:
CN201810769232.1
application date:
2018.07.13
Public/Announcement Number:
CN109021045A
applicant (patent):
Ludong University
inventor:
Liu Ying , Xia Chuan Hai , Ma Xuanxuan , Liu Sujing , Yu Junbao
National and provincial code:
Shandong; 37
Abstract:
The present invention discloses a method for simultaneous separation of glycoside, isosorbiin and chlorogenic acid from the leaves of p. Macrophylla, step elution process of eluent and purification process of Gel chromatography column; The invention takes the leaves of hemp leaves as raw material, obtains the extract of hemp leaves of hemp leaves of hemp leaves after treatment, dissolves thoroughly by distilled water and filters out insoluble matters, the filtrate was passed through a macroporous resin column and eluted with an eluent. The eluent of the first stage was concentrated and lyophilized to obtain chlorogenic acid with a purity of more than 52%, continue to use the gel column for refining, get the purity of more than 93% of the white glycosides and more than 97% of the isosorbide; the separation method in a simple process at the same time get a high purity of the white (more than 93%) and Isosorbide (more than 97%) and chlorogenic acid (more than 52%), the process is simple and feasible, high production efficiency, high utilization rate of raw materials, suitable for industrial production, has high production and practical value.
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sovereignty:
1. A method for simultaneous separation of Baima leaves from linseed, isosorbiin and chlorogenic acid, characterized by comprising a macroporous resin column adsorption process, an eluent stepwise elution process and a Gel chromatography column purification process, the operation steps are as follows: a macroporous resin column adsorption process: After drying and grinding, ethanol aqueous solution reflux extraction, extract under reduced pressure distillation to obtain the extract of hemp leaves; ultrasonic dissolution of the extracts from the leaves of hemp and hemp leaves in distilled water, filtration of insoluble matter, filtrate flow through macroporous resin column adsorption; B eluent step elution process: The macroporous resin column after adsorption is fully eluted with distilled water, collecting the eluent of the first stage, and then eluting with ethanol aqueous solution, collecting the eluent of the second stage, the eluent of the first stage is concentrated and freeze-dried to obtain chlorogenic acid with a purity of more than 52%; the product obtained by vacuum distillation of the second-stage eluate is used for the next step of refining; c gel column refining process: the product obtained by the second-stage eluate is dissolved in methanol, and the sample is applied to the gel column for refining, after elution of the eluate, the monomer eluate was collected, and then distilled under reduced pressure to obtain a purity of more than 93% of the white glycoside and more than 97% of the isosorbide.
Last Update：2023-08-16 22:05:47
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