186763-78-0
Ginsenoside Rg5
CAS: 186763-78-0
Molecular Formula: C42H70O12
186763-78-0 - Names and Identifiers
186763-78-0 - Physico-chemical Properties
| Molecular Formula | C42H70O12 |
| Molar Mass | 767 |
| Density | 1.28±0.1 g/cm3 (20 ºC 760 Torr) |
| Boling Point | 855.6±65.0 °C(Predicted) |
| Solubility | Methanol, Pyridine, DMSO |
| Appearance | White-like powder |
| pKa | 12.85±0.70(Predicted) |
| Storage Condition | 2-8°C |
| MDL | MFCD22200429 |
| Physical and Chemical Properties | White crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from ginseng. |
| In vitro study | Ginsenoside Rg5 plays a novel role as an IGF-1R agonist. Ginsenoside Rg5 binds to IGF-1R with an IC 50 value of ~90 and its angiogenic activity is inhibited by IGF-1R knockdown. To investigate the possible interaction of Ginsenoside Rg5 with IGF-1R, a docking analysis is performed. Docking results show that Ginsenoside Rg5 binds strongly at two sites, A and B, with K d values of 20 and 27 nM, respectively, to the cysteine-rich domain of IGF-1R. Pretreatment with Rg5 blocks the binding of radiolabeled IGF-1 to HUVECs with an IC 50 value of ~90 μM, which is greater than an IC 50 value of ~1.4 nM for unlabeled IGF-1. The results from MTT assay show that MCF-7 cell proliferation is inhibited by Ginsenoside Rg5 treatment for 24, 48 and 72 h in a dose-dependent manner. Ginsenoside Rg5 at different concentrations (0, 25, 50 and 100 μM), induce cell cycle arrest in G0/G1 phase through regulation of cell cycle-related proteins in MCF-7 cells. |
| In vivo study | Ginsenoside Rg5 inhibits the mRNA expression of COX-2 via suppression of the DNA binding activities of NF-κB p65 in lipopolysaccharides (LPS)-stimulated BV2 microglial cells. Rg5 pretreated group mice show declined expression of NF-κB p65 and COX-2. In the group treated with low dose of Ginsenoside Rg5 (10 mg/kg), there is remarkable tubular damage and infiltration of inflammatory cells. However, at the higher dose of Ginsenoside Rg5 (20 mg/kg), tubules markedly appeare histologically normal and no inflammation and cast formation is observed in kidney tissues. |
186763-78-0 - Reference
| Reference Show more | 1. Zhang Daoming, Zhang Qi, Liu Linlin, Ren Hui. Ginsenoside Rg5 promotes apoptosis of esophageal cancer Bcl-2 cells by down-regulating Eca-109 protein [J]. Chinese laboratory diagnostics 2018 22(04):700-703. 2. Shen Junyi Zhao Zhiming Liu Chunli Xu Zi Han Cai Hui. Effects of ginsenoside on the expression of MEG3 in rat cerebral vascular endothelial cells and the promotion of angiogenesis [J]. Chinese Journal of Traditional Chinese Medicine 2019 34(08):3418-3421. 3. Liu Huiying, Wang Chengxiao, Yang Ye, etc. Microwave-assisted degradation of Panax notoginseng saponins to produce ginsenoside Rg_5 [J]. Chinese herbal medicine, 2018, v.49;No.625(14):58-64. 4. Dong Kunyuan, Yu Yu, Xiong Jin Road, etc. Study on fingerprint of red ginseng based on high performance liquid chromatography and chemometrics [J]. Journal of Food Safety and quality testing, 2019, 010(021):7316-7321. 5. Zhang Na, Huang Xin, Guo Yunlong, Yue Hao, Liu Shuying. Distribution of ginsenosides in panax ginseng from different habitats based on multi-index statistical analysis UPLC-QQQ-MS [J]. Specialty research, 2020,42(06):48-54. 6. Zhao caixiu, Wang Nan, Huang Xin, Yue Hao, Guo Yunlong, Liu Shuying. Characterization and whole genome sequencing of ginsenoside Rb1 transformed by Bacillus subtilis JLGA-SD-28 [J]. Chinese traditional medicines, 2021,43(02):518-523. 7. Shao Zijun, Li Zhiman, Yu Pengcheng, Chen Jianbo, Li Shanshan, Sun Yinshi. Transformation of rare ginsenosides from Panax notoginseng flower by amino acids and effects of extracts on activity of RAW264.7 cells induced by lipopolysaccharide [J]. Chinese herbal medicine, 2021,52(03):702-710. 8. [IF = 6.06] Jiahong Han et al."Compatibility effects of ginseng and Ligustrum lucidum Ait herb pair on hematopoietic recovery in mice with cyclophosphamide-induced myelosuppression and its material basis."J Ginseng Res. 2020 Mar;44:291 9. [IF=5.34] Shan-Shan Zhou et al."Stronger anti-obesity effect of white ginseng over red ginseng and the potential mechanisms involving chemically structural/compositional specificity to gut microbiota."Phytomedicine. 2020 Aug;74:152761 10. [IF=3.935] Shan-Shan Zhou et al."Synchronous characterization of carbohydrates and ginsenosides yields deeper insights into the processing chemistry of ginseng."J Pharmaceut Biomed. 2017 Oct;145:59 11. [IF=4.411] Jianbo Chen et al."Neuroprotective Effects of Red Ginseng Saponins in Scopolamine-Treated Rats and Activity Screening Based on Pharmacokinetics."Molecules. 2019 Jan;24(11):2136 12. [IF=4.142] Wang Chenxi et al."Rapid discovery of potential ADR compounds from injection of total saponins from Panax notoginseng using data-independent acquisition untargeted metabolomics."Analytical And Bioanalytical Chemistry. 2021 Oct 26 13. [IF=3.935] Ruimei Lin et al."Global identification and determination of the major constituents in Kai-Xin-San by ultra-performance liquid chromatography-quadrupole-Orbitrap mass spectrometry and gas chromatography-mass spectrometry."J Pharmaceut Biomed. 2021 Nov;206 14. [IF=3.645] Mengmeng Jia et al."UHPLC coupled with mass spectrometry and chemometric analysis of Kang-Ai injection based on the chemical characterization, simultaneous quantification, and relative quantification of 47 herbal alkaloids and saponins."J Sep Sci. 2020 Ju 15. [IF=3.503] Jiajia Dong et al."Comparative pharmacokinetic analysis of raw and steamed Panax notoginseng roots in rats by UPLC-MS/MS for simultaneously quantifying seven saponins."Pharm Biol. 2021;59(1):653-661 16. [IF=6.06] Qingxia Huang et al."Major ginsenosides from Panax ginseng promote aerobic cellular respiration and SIRT1-mediated mitochondrial biosynthesis in cardiomyocytes and neurons."J Ginseng Res. 2022 Feb;: 17. [IF=6.576] Zhi-man Li et al."Transformation Mechanism of Rare Ginsenosides in American Ginseng by Different Processing Methods and Antitumour Effects."Frontiers in Nutrition. 2022; 9: 833859 18. [IF=1.885] Guo Na et al."Comparison of the Saponins in Three Processed American Ginseng Products by Ultra-High Performance Liquid Chromatography-Quadrupole Orbitrap Tandem Mass Spectrometry and Multivariate Statistical Analysis."International Journal of Analytical Ch |
186763-78-0 - Reference Information
| Plant Source: | ginseng |
| Introduction | ginsenoside RG5 is extracted from distilled ginseng and can be used for content determination/identification/pharmacological experiments. |
| biological activity | Ginsenoside Rg5 is the main component of red ginseng. Ginsenoside Rg5 blocks IGF-1 of binding to its receptor with an IC50 of approximately 90 nM. Ginsenoside Rg5 also inhibits the mRNA expression of COX-2 by inhibiting the DNA-binding activity of NF-κB p65. |
| Use | for content determination/identification/pharmacological experiments, etc. Ginsenoside Rg5 is the main component extracted from steamed ginseng and has anti-inflammatory effect. |
Last Update：2024-04-09 20:45:29
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Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
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