1874-54-0

Name	psicofuranine
Synonyms	U-9586 psicofuranine Angustmycin C Psicofuranosyladenine 1'-(Hydroxymethyl)adenosine Psicofuranine [AngustMycin C] 9-β-D-Psicofuranosyl-9H-purin-6-amine 9-(β-D-Psicofuranosyl)-9H-purin-6-amine
CAS	1874-54-0

Molecular Formula	C11H15N5O5
Molar Mass	297.27
Density	2.02±0.1 g/cm3(Predicted)
Melting Point	212-214℃ (decomposition)
Boling Point	720.1±70.0 °C(Predicted)
Specific Rotation(α)	D25 -68° (dimethylformamide)
pKa	12.87±0.70(Predicted)
Storage Condition	-20 ℃, sealed, dry
In vitro study	Psicofuranine specifically inhibits bacterial GMP synthase as demonstrated by isolation of Psicofuranine-resistant Escherichia coli mutants with mutations in the gene encoding GMP synthase and inhibition of bacterial growth. Psicofuranine exhibits a dose-dependent inhibition of P. falciparum growth with an IC 50 of 0.3 mM. The Psicofuranine inhibitory concentration is similar to that of E. coli .

biological activity	Psicofuramine is a nucleoside antibiotic that inhibits xanthine 5 '-phosphate aminotransferase. Psicofuramine can also specifically inhibit GMP synthase and interrupt the growth of parasites. Psicofuramine has a dose-dependent inhibitory effect on the growth of Plasmodium falciparum.
Target	Xanthosine 5 '-phosphate aminase P. falciparum E. coli

Last Update：2024-04-09 21:01:54

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1874-54-0
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